AGE-DEPENDENT ACQUIRED PROTECTION AGAINST PLASMODIUM-FALCIPARUM IN PEOPLE HAVING 2 YEARS EXPOSURE TO HYPERENDEMIC MALARIA
AGE-DEPENDENT ACQUIRED PROTECTION AGAINST PLASMODIUM-FALCIPARUM IN PEOPLE HAVING 2 YEARS EXPOSURE TO HYPERENDEMIC MALARIA
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DOI：
10.4269/ajtmh.1991.45.65
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发表时间：
1991-07-01
影响因子：
3.3
通讯作者：
MASBAR, S
中科院分区：
文献类型：
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作者：
BAIRD, JK;JONES, TR;MASBAR, S
一项关于恶性疟原虫对频繁和高级别寄生虫血症易感性的流行病学研究表明，在暴露于高流行病感染压力的两年内，年龄依赖性获得性保护作用得以发展。这项研究是在印度尼西亚伊里安查亚东北部的一个村庄进行的，其中一半居民是该省的本地人，另一半是来自爪哇地区的移民，那里很少或根本没有疟疾传播。对240名志愿者每两周进行一次为期4个月的监测，结果得出5种不同的措施对恶性疟原虫无性寄生虫血症的易感性。增加保护作为年龄的函数之间的爪哇人是一个一致的模式之间的五个估计的易感性。这些与年龄有关的保护功能在数量上与伊里安查亚终身居民的保护功能相似。当通过ELISA测量对环状感染红细胞表面抗原（RESA）的体液免疫应答时，出现了类似的模式; RESA抗体的相对水平在两个亚群中作为年龄的平行函数增加。对恶性疟原虫的获得性保护性免疫不是多年大量暴露于抗原的累积产物。相反，保护的全部好处似乎发展得很快。保护程度受近期暴露和年龄的影响，与慢性重度暴露史无关。
An epidemiologic study of susceptibility to frequent and high-grade parasitemia by Plasmodium falciparum revealed that age-dependent acquired protection developed within a two-year period of exposure to hyperendemic infection pressure. The study was conducted in a single village in northeastern Irian Jaya, Indonesia, where half the residents were native to the province and the other half were transmigrants from areas of Java, where there is little or no malaria transmission. Five separate measures of susceptibility to the asexual parasitemia of falciparum malaria were derived from results of four months of biweekly surveillance of 240 volunteers. Increasing protection as a function of age among the Javanese was a consistent pattern among the five estimates of susceptibility. These age-dependent functions of protection were quantitatively parallel to those among life-long residents of Irian Jaya. When humoral immune responsiveness to ring-infected erythrocyte surface antigen (RESA) was measured by ELISA, a similar pattern emerged; the relative level of antibody to RESA increased as parallel functions of age among the two subpopulations. Acquired protective immunity against P. falciparum was not the cumulative product of many years of heavy exposure to antigen. Instead, the full benefit of protection appeared to develop quickly. The degree of protection was governed by recent exposure and age, independent of history of chronic heavy exposure.