In vivo magnetic resonance imaging at 11.7 Tesla visualized the effects of neunatal transection of infaraorbital nerve upon primary and secondary trigeminal pathways in rats
In vivo magnetic resonance imaging at 11.7 Tesla visualized the effects of neunatal transection of infaraorbital nerve upon primary and secondary trigeminal pathways in rats
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11.7 特斯拉体内磁共振成像显示了新生儿眶下神经横断对大鼠初级和次级三叉神经通路的影响
DOI：
10.1016/j.brainres.2014.07.013
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发表时间：
2014
期刊：
影响因子：
2.9
通讯作者：
J.
中科院分区：
文献类型：
--
作者：
Ooi;Y.;Inui-Yamamoto;C.;Suzuki;T.;Nakadate;H.;Nagase;Y.;Seiyama;A.;Yoshioka;Y. and Seki;J.
本研究采用11.7T超高场T2加权成像技术，研究新生大鼠眶下神经切断后三叉神经初级通路和次级通路的病理变化。三叉神经通路由三叉神经脊束、三叉神经感觉核复合体、内侧丘脑内侧束、延髓外板腹内侧部和丘脑腹后核组成。通过选择最佳的MRI参数，如重复时间、回声时间和切片方向，本研究在没有任何造影剂的情况下可视化了大鼠的三叉神经通路。在8周龄时，由于神经切断引起的病理改变，与受损神经相连的三叉神经通路的面积明显减少。此外，三叉神经主干和三叉神经脊束的T2加权磁共振图像显示脑脊液通过三叉神经在脑干内外之间传递。这些结果支持了超高场MRI系统用于无创性评估三叉神经损伤对三叉神经通路的影响。
Using 11.7 T ultra high-field T2-weighted MRI, the present study aimed to investigate pathological changes of primary and secondary trigeminal pathways following neonatal transection of infraorbital nerve in rats. The trigeminal pathways consist of spinal trigeminal tract, trigeminal sensory nuclear complex, medial lemniscus, ventromedial portion of external medullary lamina and ventral posterior nucleus of thalamus. By selecting optimum parameters of MRI such as repetition time, echo time, and slice orientation, this study visualized the trigeminal pathways in rats without any contrast agents. Pathological changes due to the nerve transection were found at 8 weeks of age as a marked reduction of the areas of the trigeminal pathways connecting from the injured nerve. In addition, T2-weighted MR images of the trigeminal nerve trunk and the spinal trigeminal tract suggest a communication of CSF through the trigeminal nerve between the inside and outside of the brain stem. These results support the utility of ultra high-field MRI system for noninvasive assessment of effects of trigeminal nerve injury upon the trigeminal pathways.