Rhinal-hippocampal connectivity determines memory formation during sleep
Rhinal-hippocampal connectivity determines memory formation during sleep
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DOI：
10.1093/brain/awh647
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发表时间：
2006-01-01
期刊：
影响因子：
14.5
通讯作者：
Helmstaedter, C
中科院分区：
文献类型：
--
作者：
Fell, J;Fernández, G;Helmstaedter, C
与清醒状态的注意相比，意志和语义加工在睡眠中的作用较小。因此，研究睡眠期间陈述性记忆的形成可能使我们能够分离出记忆的核心过程。睡眠中记忆形成最可行的方法是分析梦的记忆。损伤和成像研究表明，陈述性记忆的编码，即有意识地可访问的事件和事实，取决于鼻皮层和海马体，内侧颞叶的两个亚结构内的操作。成功的记忆形成伴随着短暂的脑-海马相互作用。因此，记忆梦的能力可能与中时连接有关。因此，我们记录了12名癫痫患者（8名女性，平均年龄41.1 ± 6.4岁）在睡眠期间植入鼻和海马深度电极的EEG。他们在快速眼动睡眠（REM）期间被唤醒，并被要求回忆他们的梦想。通过连贯性分析，我们发现，与记忆力差的患者相比，具有良好的梦回忆的患者的海马-海马连接值大约是其两倍。这表明，海马连接是决定陈述性记忆形成的关键因素。
Compared with waking state attention, volition and semantic processing play a minor role during sleep. Thus, investigating declarative memory formation during sleep may allow us to isolate mnemonic core processes. The most feasible approach to memory formation during sleep is the analysis of dream memories. Lesion and imaging studies have demonstrated that encoding of declarative memories, i.e. consciously accessible events and facts, depends on operations within the rhinal cortex and the hippocampus, two substructures of the medial temporal lobe. Successful memory formation is accompanied by a transient rhinal-hippocampal interaction. Consequently, the ability to memorize dreams may be related to mediotemporal connectivity. Therefore, we recorded EEG during sleep from rhinal and hippocampal depth electrodes implanted in 12 epilepsy patients (eight women, mean age 41.1 +/- 6.4 years). They were awakened during rapid eye movement sleep (REM) and asked to recall their dream. Via coherence analyses we show that rhinal-hippocampal connectivity values are approximately twice as large for patients with good dream recall versus those patients with poor recall. This suggests that rhinal-hippocampal connectivity is a key factor in determining declarative memory formation.