Adenovirus Early Proteins and Host Sumoylation.
Adenovirus Early Proteins and Host Sumoylation.
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DOI：
10.1128/mbio.01154-16
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发表时间：
2016-09-20
期刊：
影响因子：
6.4
通讯作者：
Hearing P
中科院分区：
文献类型：
--
作者：
Sohn SY;Hearing P
人腺病毒基因组被转运到细胞核中，在细胞核中发生病毒基因转录、病毒DNA复制和病毒体组装。小泛素样修饰物（SUMO）的翻译后修饰涉及多种细胞过程的调节，特别是核事件。因此，腺病毒调节和利用宿主sumoylation系统并不奇怪。腺病毒早期蛋白通过刺激细胞周期和抵消宿主的抗病毒防御，在感染细胞内建立病毒复制的最佳宿主环境中发挥重要作用。在这里，我们回顾了人类腺病毒早期蛋白和宿主类小泛素化系统之间相互作用的机制和功能后果的研究结果。
The human adenovirus genome is transported into the nucleus, where viral gene transcription, viral DNA replication, and virion assembly take place. Posttranslational modifications by small ubiquitin-like modifiers (SUMOs) are implicated in the regulation of diverse cellular processes, particularly nuclear events. It is not surprising, therefore, that adenovirus modulates and utilizes the host sumoylation system. Adenovirus early proteins play an important role in establishing optimal host environments for virus replication within infected cells by stimulating the cell cycle and counteracting host antiviral defenses. Here, we review findings on the mechanisms and functional consequences of the interplay between human adenovirus early proteins and the host sumoylation system.