The genetic and molecular regulation of sleep: from fruit flies to humans.

The genetic and molecular regulation of sleep: from fruit flies to humans.
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DOI:
10.1038/nrn2683
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发表时间:
2009-08
影响因子:
34.7
通讯作者:
Cirelli, Chiara
Cirelli, Chiara
中科院分区:
医学1区
文献类型:
--
作者:
Cirelli, Chiara

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人们早就知道遗传因素会影响睡眠的数量和质量。基因筛选发现了几种影响不同物种睡眠的突变,指出了一种进化保守的睡眠调节。此外,人们还认识到睡眠会影响基因的表达。这些发现为睡眠调节和功能的分子基础提供了有价值的线索,可能会导致更有效地治疗睡眠障碍。
It has been known for a long time that genetic factors affect sleep quantity and quality. Genetic screens identified several mutations that affect sleep across species, pointing to an evolutionary conserved regulation of sleep. Moreover, it has also been recognized that sleep affects the expression of genes. These findings have given valuable clues about the molecular underpinnings of sleep regulation and function that might lead the way to more efficient treatments for sleep disorders.
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