Brain-derived extracellular vesicles mediate traumatic brain injury associated multi-organ damage.
Brain-derived extracellular vesicles mediate traumatic brain injury associated multi-organ damage.
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DOI：
10.1016/j.bbrc.2023.04.119
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发表时间：
2023-05
影响因子：
3.1
通讯作者：
Fanjian Li;Yafan Liu;Lei Li;Ruilong Peng;Cong Wang;Chuan Liu;Mingming Shi;Yiyao Cao;
中科院分区：
文献类型：
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作者：
Fanjian Li;Yafan Liu;Lei Li;Ruilong Peng;Cong Wang;Chuan Liu;Mingming Shi;Yiyao Cao;
创伤性脑损伤（TBI）会对全身器官产生负面影响，从而导致更多的死亡和残疾。然而，TBI对全身器官影响的机制仍不清楚。在以前的工作中，我们发现，脑源性细胞外囊泡（BDEV）从受伤的大脑释放可以诱导全身凝血与广泛的纤维蛋白沉积在肺，肾和心脏的微血管系统中的TBI小鼠模型。在这项研究中，我们研究了BDEV是否可以诱导TBI小鼠的心脏，肺，肝脏和肾脏损伤。病理染色和相关生物标志物的结果表明，BDEV可引起组织学损害和系统功能障碍。活体成像系统显示BDEV可在全身器官聚集。我们还发现BDEV可以诱导肺、肝、心和肾中的细胞凋亡。此外，我们发现BDEV可引起多器官内皮细胞损伤。最后，这种继发性多器官损伤可以通过清除循环中的BDEV来缓解。我们的研究为TBI相关多器官损伤提供了新的视角和潜在的机制。
Traumatic brain injury (TBI) can negatively impact systemic organs, which can lead to more death and disability. However, the mechanism underlying the effect of TBI on systemic organs remains unclear. In previous work, we found that brain-derived extracellular vesicles (BDEVs) released from the injured brain can induce systemic coagulation with a widespread fibrin deposition in the microvasculature of the lungs, kidney, and heart in a mouse model of TBI. In this study, we investigated whether BDEVs can induce heart, lung, liver, and kidney injury in TBI mice. The results of pathological staining and related biomarkers indicated that BDEVs can induce histological damage and systematic dysfunction. In vivo imaging system demonstrated that BDEVs can gather in systemic organs. We also found that BDEVs could induce cell apoptosis in the lung, liver, heart, and kidney. Furthermore, we discovered that BDEVs could cause multi-organ endothelial cell damage. Finally, this secondary multi-organ damage could be relieved by removing circulating BDEVs. Our research provides a novel perspective and potential mechanism of TBI-associated multi-organ damage.