Assessing human 5-HT function in vivo with pharmacoMRI
Assessing human 5-HT function in vivo with pharmacoMRI
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DOI：
10.1016/j.neuropharm.2008.06.029
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发表时间：
2008-11-01
影响因子：
4.7
通讯作者：
Deakin, J. F. W.
中科院分区：
文献类型：
--
作者：
Anderson, I. M.;McKie, S.;Deakin, J. F. W.
许多使用磁共振成像（MRI）来可视化药物对动物和人类大脑的作用的新方法（pharmacMRI或phMRI）正在成为转化精神药理学的既定工具。使用已知药理学的药物，可以研究神经递质系统如何参与其他过程的神经系统，如认知挑战（调制phMRI）或检查药物本身在大脑中的急性作用（挑战phMRI）。在这篇文章中，我们讨论了phMRI背后的原则，并回顾了研究5-羟色胺（5-HT）的操纵效果。5-HT调制phMRI研究表明，5-HT参与了广泛的神经过程，从运动功能到“冷”认知，如记忆和反应抑制，再到情绪处理。我们强调了在大脑区域中的发现，这些发现在不同的研究中表现出一定的一致性或互补性，例如腹外侧眶额皮质，其中5-HT的调制是任务特异性的，以及杏仁核在情绪处理中，其中5-HT主要是抑制性的。5-HT激发phMRI是有希望的，但迄今为止很少有研究已经进行。分析phMRI数据的新方法包括连通性分析，它有望超越识别激活/调制的孤立区域，以了解功能电路及其神经化学。现在需要将5-HT phMRI纳入患者人群，并且需要开发研究治疗效果的方法。如果这是成功的，那么phMRI将提供一个真正令人兴奋的机会，为更好的治疗精神疾病的快速发展。(C)2008爱思唯尔有限公司保留所有权利。
A number of novel ways of using magnetic resonance imaging (MRI) to visualise the action of drugs on animal and human brain (pharmacoMRI or phMRI) are becoming established tools in translational psychopharmacology. Using drugs with known pharmacology it is possible to investigate how neurotransmitter systems are involved in neural systems engaged by other processes, such as cognitive challenge (modulation phMRI) or to examine the acute effects of the drug itself in the brain (challenge phMRI). In this article we discuss the principles behind phMRI and review studies investigating the effect of serotonin (5-HT) manipulations. 5-HT modulation phMRI studies show the involvement of 5-HT in a broad range of neural processes ranging from motor function through 'cold' cognition, such as memory and response inhibition, to emotional processing. We highlight findings in brain areas that show some consistency or complementarity across studies, such as the ventrolateral orbitofrontal cortex where modulation by 5-HT is task-specific, and the amygdala in emotional processing where 5-HT is predominantly inhibitory. 5-HT challenge phMRI is promising but as yet few studies have been carried out. New ways of analysing phMRI data include connectivity analysis which holds the promise of going beyond identifying isolated areas of activation/modulation to understanding functional circuits and their neurochemistry. 5-HT phMRI now needs to be taken into patient populations and methods of investigating treatment effects need to be developed. If this is successful then phMRI will provide a genuinely exciting opportunity for the rapid development of better treatments for psychiatric conditions. (C) 2008 Elsevier Ltd. All rights reserved.