Conceptual Knowledge Is Underpinned by the Temporal Pole Bilaterally: Convergent Evidence from rTMS
Conceptual Knowledge Is Underpinned by the Temporal Pole Bilaterally: Convergent Evidence from rTMS
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DOI：
10.1093/cercor/bhn131
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发表时间：
2009-04-01
期刊：
影响因子：
3.7
通讯作者：
Jefferies, Elizabeth
中科院分区：
文献类型：
--
作者：
Ralph, Matthew A. Lambon;Pobric, Gorana;Jefferies, Elizabeth
概念知识为我们为世界带来意义提供了基础。对语义痴呆患者的研究和一些功能性神经影像学研究表明，双侧前颞叶是形成语义表征的核心神经基质。然而，这一假设仍然存在争议，因为传统的理解神经模型并没有为这些区域设定作用。为了对这场争论进行裁决，我们进行了两项新颖的实验，这些实验使用离线、低频、重复经颅磁刺激来暂时扰乱左侧或右侧颞极 (TP) 的神经处理。通过此过程，做出语义决策所需的时间显着减慢，但具体而言。结果证实，两个 TP 都构成了神经网络内支持概念知识的关键基础。
Conceptual knowledge provides the basis on which we bring meaning to our world. Studies of semantic dementia patients and some functional neuroimaging studies indicate that the anterior temporal lobes, bilaterally, are the core neural substrate for the formation of semantic representations. This hypothesis remains controversial, however, as traditional neurological models of comprehension do not posit a role for these regions. To adjudicate on this debate, we conducted 2 novel experiments that used off-line, low-frequency, repetitive transcranial magnetic stimulation to disrupt neural processing temporarily in the left or right temporal poles (TPs). The time required to make semantic decisions was slowed considerably, yet specifically, by this procedure. The results confirm that both TPs form a critical substrate within the neural network that supports conceptual knowledge.