OVARIAN-CARCINOMA - IMPROVED SURVIVAL FOLLOWING ABDOMINO-PELVIC IRRADIATION IN PATIENTS WITH A COMPLETED PELVIC OPERATION
OVARIAN-CARCINOMA - IMPROVED SURVIVAL FOLLOWING ABDOMINO-PELVIC IRRADIATION IN PATIENTS WITH A COMPLETED PELVIC OPERATION
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DOI：
10.1016/0002-9378(79)90950-5
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发表时间：
1979-01-01
影响因子：
9.8
通讯作者：
REID, JG
中科院分区：
文献类型：
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作者：
DEMBO, AJ;BUSH, RS;REID, JG
一项前瞻性、分层、随机研究纳入了 190 名 IB、II 和 III 期（无症状）卵巢癌术后患者。中位随访时间为 52 个月。由于广泛的盆腔肿瘤而无法完成双侧输卵管卵巢切除术和子宫切除术（BSOH）的患者预后不良，对于任何测试的疗法都没有差异。完成 BSOH 后，无膈肌屏蔽的盆腔加腹盆腔放疗 (P + AB) 显着提高了患者的生存率，并且与单独盆腔放疗或随后每日辅助苯丁酸氮芥[一种抗肿瘤剂]治疗相比，患者的存活率和隐匿性上腹部疾病的长期控制增加了约 25%。 P + AB 在 BSOH 完成患者中的有效性与分期或肿瘤分级无关，并且在所有肉眼肿瘤均已切除的患者中最为明显。苯丁酸氮芥添加到盆腔照射中延迟了治疗失败的时间，但没有减少治疗失败的次数。
A prospective, stratified, randomized study of 190 postoperative ovarian carcinoma patients with Stages IB, II, and III (asymptomatic) presentations is reported. The median time of follow-up was 52 mo. Patients in whom bilateral salpingo-oophorectomy and hysterectomy (BSOH) could not be completed because of extensive pelvic tumor had a poor prognosis which did not differ for any of the therapies tested. When BSOH was completed, pelvic plus abdominopelvic irradiation (P + AB) with no diaphragmatic shielding significantly improved patient survival rate and long-term control of occult upper abdominal disease in approximately 25% more patients than pelvic irradiation alone or followed by adjuvant daily chlorambucil [an antitumor agent] therapy. The effectiveness of P + AB in BSOH-completed patients was independent of stage or tumor grade and was most clearly appreciated in patients with all gross tumor removed. Chlorambucil added to pelvic irradiation delayed the time to treatment failure without reducing the number of treatment failures.