Kynurenic acid levels are elevated in the cerebrospinal fluid of patients with schizophrenia
Kynurenic acid levels are elevated in the cerebrospinal fluid of patients with schizophrenia
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DOI：
10.1016/s0304-3940(01)02242-x
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发表时间：
2001-11-02
影响因子：
2.5
通讯作者：
Engberg, G
中科院分区：
文献类型：
--
作者：
Erhardt, S;Blennow, K;Engberg, G
犬尿烯酸是一种内源性谷氨酸拮抗剂，在N-甲基o-天冬氨酸受体的甘氨酸位点具有优先作用。越来越多的证据表明，该化合物显着参与大脑中的基础神经生理过程。采用高压液相色谱法和荧光检测法对28例男性精神分裂症患者和17例男性健康对照者脑脊液中犬尿烯酸进行了检测。与对照组（0.97 +/-0.07 nM）相比，精神分裂症患者的CSF犬尿烯酸水平升高（1.67 +/-0.27 nM）。此外，还发现精神分裂症患者的CSF犬尿烯酸水平与年龄相关。本研究结果表明犬尿烯酸在精神分裂症发病机制中的作用。(C)2001爱思唯尔科学爱尔兰有限公司保留所有权利。
Kynurenic acid is an endogenous glutamate antagonist with a preferential action at the glycine-site of the N-methyl o-aspartate-receptor. Mounting evidence indicate that the compound is significantly involved in basal neurophysiological processes in the brain. In the present investigation, cerebrospinal fluid (CSF) level of kynurenic acid was analyzed in 28 male schizophrenic patients and 17 male healthy controls by means of high pressure liquid chromatography and fluorescence detection. Schizophrenic patients showed elevated CSF levels of kynurenic acid (1.67 +/- 0.27 nM) compared to the control group (0.97 +/- 0.07 nM). Furthermore, CSF levels of kynurenic acid in schizophrenic patients were also found to correlate with age. The present finding is indicative of a contribution of kynurenic acid in the pathogenesis of schizophrenia. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.