In vivo hemodynamic analysis of intracranial aneurysms obtained by magnetic resonance fluid dynamics (MRFD) based on time-resolved three-dimensional phase-contrast MRI
In vivo hemodynamic analysis of intracranial aneurysms obtained by magnetic resonance fluid dynamics (MRFD) based on time-resolved three-dimensional phase-contrast MRI
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DOI：
10.1007/s00234-009-0635-3
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发表时间：
2010-10-01
期刊：
影响因子：
2.8
通讯作者：
Sakahara, Harumi
中科院分区：
文献类型：
--
作者：
Isoda, Haruo;Ohkura, Yasuhide;Sakahara, Harumi
血流动力学被认为在颅内动脉瘤的发生、生长和破裂中起着非常重要的作用。我们的研究目的是利用时间分辨三维相对比MRI （4D-Flow）在1.5 T下对未破裂的颅内动脉瘤进行磁共振流体动力学的体内血流动力学分析，并分析血流动力学与壁面剪切应力（WSS）和振荡剪切指数（OSI）的关系。这项研究包括了9个有14个未破裂动脉瘤的受试者。4D-Flow通过1.5 t头线圈磁共振扫描仪进行。我们基于4D-Flow软件计算颅内动脉瘤的活体流线、WSS和OSI。我们评估了动脉瘤内螺旋流的数量，并比较了血管与动脉瘤之间以及整个动脉瘤与螺旋流顶点之间WSS或OSI的差异。所有颅内动脉瘤均获得心期任意方向的三维流线、WSS和OSI分布图。12个动脉瘤各有一个螺旋流，2个动脉瘤各有两个螺旋流。与血管相比，动脉瘤的WSS较低，OSI较高。相对于整个动脉瘤，螺旋流顶点的WSS较低，OSI较高。本研究中每个颅内动脉瘤至少有一个螺旋流。螺旋流顶点处的WSS较低，OSI高于整个瘤壁。
Hemodynamics is thought to play a very important role in the initiation, growth, and rupture of intracranial aneurysms. The purpose of our study was to perform in vivo hemodynamic analysis of unruptured intracranial aneurysms of magnetic resonance fluid dynamics using time-resolved three-dimensional phase-contrast MRI (4D-Flow) at 1.5 T and to analyze relationships between hemodynamics and wall shear stress (WSS) and oscillatory shear index (OSI).This study included nine subjects with 14 unruptured aneurysms. 4D-Flow was performed by a 1.5-T magnetic resonance scanner with a head coil. We calculated in vivo streamlines, WSS, and OSI of intracranial aneurysms based on 4D-Flow with our software. We evaluated the number of spiral flows in the aneurysms and compared the differences in WSS or OSI between the vessel and aneurysm and between whole aneurysm and the apex of the spiral flow.3D streamlines, WSS, and OSI distribution maps in arbitrary direction during the cardiac phase were obtained for all intracranial aneurysms. Twelve aneurysms had one spiral flow each, and two aneurysms had two spiral flows each. The WSS was lower and the OSI was higher in the aneurysm compared to the vessel. The apex of the spiral flow had a lower WSS and higher OSI relative to the whole aneurysm.Each intracranial aneurysm in this study had at least one spiral flow. The WSS was lower and OSI was higher at the apex of the spiral flow than the whole aneurysmal wall.