Nanochemoprevention with therapeutic benefits: An updated review focused on epigallocatechin gallate delivery
Nanochemoprevention with therapeutic benefits: An updated review focused on epigallocatechin gallate delivery
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DOI：
10.1080/10408398.2019.1565490
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发表时间：
2019-02
影响因子：
10.2
通讯作者：
Qiong-Qiong Yang-Qiong;Xin-Lin Wei;Yasi Fang;R. Gan;Min Wang;Ying-Ying Ge-Ying;Dan-Wei Zhang;Li-Zeng Cheng-Li-Zeng
中科院分区：
文献类型：
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作者：
Qiong-Qiong Yang-Qiong;Xin-Lin Wei;Yasi Fang;R. Gan;Min Wang;Ying-Ying Ge-Ying;Dan-Wei Zhang;Li-Zeng Cheng-Li-Zeng
摘要表没食子儿茶素没食子酸酯（Epigallocatechin gallate，EGCG）是一种天然酚类化合物，广泛存在于植物中，尤其是绿色茶中，具有抗氧化、抗癌、抗微生物、抗糖尿病、抗肥胖等多种保健功能。尽管表没食子儿茶素没食子酸酯具有巨大的治疗潜力，但其生物利用度低限制了其临床应用。然而，EGCG的纳米制剂正在成为传统制剂的新替代品。本文综述了各种EGCG纳米颗粒的纳米化学预防应用，如基于脂质的，基于聚合物的，基于碳水化合物的，基于蛋白质的和基于金属的纳米颗粒。与这些纳米载体杂交的EGCG能够实现高级功能，如靶向释放，主动靶向和增强渗透，最终提高EGCG的生物利用度。此外，本文还总结了EGCG在治疗应用中面临的挑战，并提出了未来的发展方向。
Abstract Epigallocatechin gallate (EGCG) is a natural phenolic compound found in many plants, especially in green tea, which is a popular and restorative beverage with many claimed health benefits such as antioxidant, anti-cancer, anti-microbial, anti-diabetic, and anti-obesity activities. Despite its great curative potential, the poor bioavailability of EGCG restricts its clinical applcation. However, nanoformulations of EGCG are emerging as new alternatives to traditional formulations. This review focuses on the nanochemopreventive applications of various EGCG nanoparticles such as lipid-based, polymer-based, carbohydrate-based, protein-based, and metal-based nanoparticles. EGCG hybridized with these nanocarriers is capable of achieving advanced functions such as targeted release, active targeting, and enhanced penetration, ultimately increasing the bioavailability of EGCG. In addition, this review also summarizes the challenges for the use of EGCG in therapeutic applications, and suggests future directions for progress.