Nuclear localisation of glutathione S-transferase π is an evaluation factor for drug resistance in gynaecological cancers
Nuclear localisation of glutathione S-transferase π is an evaluation factor for drug resistance in gynaecological cancers
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DOI：
10.1016/j.clon.2004.11.008
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发表时间：
2005-06-01
影响因子：
3.4
通讯作者：
Ishimaru, T
中科院分区：
文献类型：
--
作者：
Soh, Y;Goto, S;Ishimaru, T
目的：核谷胱甘肽s -转移酶pi （GST pi）具有抗癌药物对癌细胞的保护作用。本研究的目的是评估核GST pi在妇科癌症中的临床意义。材料与方法：我们对43例上皮性卵巢癌进行GST pi的免疫组化分析，并检测核GST pi的表达与预后的相关性。我们比较了宫颈癌和子宫内膜癌化疗前后的表达水平。结果：核GST阳性组5年无进展生存率低于细胞质GST阳性组，显著低于阴性组（14.3% vs 34.8% vs 66.7%; P = 0.041）。比较子宫癌和子宫内膜癌化疗前后核GST pi的表达。12例患者中8例（66.7%）化疗后表达转为阳性。结论：我们认为GST pi的核定位与耐药有关。GST pi在肿瘤细胞中的核定位是一种有用的预测因子，并可能有助于妇科癌症抗癌药物的选择。(c) 2005年皇家放射科医师学院。Elsevier Ltd.出版。版权所有。
Aims: Nuclear glutathione S-transferase pi (GST pi) has been reported to protect cancer cells against anticancer drugs. The aim of the present study was to evaluate the clinical significance of nuclear GST pi in gynaecological cancer.Materials and methods: We carried out an immunohistochemical analysis of GST pi, and examined the correlation between nuclear GST pi expression and prognosis in 43 epithelial ovarian cancers. We compared expression levels before and after chemotherapy in uterine cervical cancers and endometrial cancers.Results: The 5-year progression-free survival rate of the nuclear GST pi-positive group was lower than that of the cytoplasmic GST pi-positive group, and was significantly lower than that of the negative group (14.3% vs 34.8% vs 66.7%; P = 0.041). The expression of nuclear GST pi was compared before and after chemotherapy in uterine cervical and endometrial cancers. In eight out of 12 cases (66.7%), the expression turned positive after the chemotherapy.Conclusions: We suggest that nuclear localisation of GST pi is associated with drug resistance. The nuclear localisation of GST pi in tumour cells is a useful prognosticator, and may contribute to the selection of anticancer drugs for gynaccological cancers. (c) 2005 The Royal College of Radiologists. Published by Elsevier Ltd. All rights reserved.