Endothelial dysfunction in MELAS improved by L-arginine supplementation
Endothelial dysfunction in MELAS improved by L-arginine supplementation
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DOI：
10.1212/01.wnl.0000220197.36849.1e
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发表时间：
2006-06-13
期刊：
影响因子：
9.9
通讯作者：
Matsuishi, T
中科院分区：
文献类型：
--
作者：
Koga, Y;Akita, Y;Matsuishi, T
作者通过血流介导的血管舒张（FMD）评价了MELAS（线粒体肌病、脑病、乳酸酸中毒和卒中）患者的内皮功能，发现与对照组相比内皮功能显著降低。两年的补充口服L-精氨酸，一氧化氮前体，显着改善内皮功能的控制水平，并与患者的L-精氨酸的正常血浆水平相协调。L-精氨酸治疗改善了内皮功能障碍，并显示出治疗MELAS卒中样发作的前景。
The authors evaluated endothelial function in patients with MELAS ( mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke) by flow-mediated vasodilation (FMD) and found a significant decrease vs controls. Two years of supplementation with oral L-arginine, a nitric oxide precursor, significantly improved endothelial function to control levels and was harmonized with the normalized plasma levels of L-arginine in patients. L-Arginine therapy improved endothelial dysfunction and showed promise in treating strokelike episodes in MELAS.