Studies on cyclic nucleotides in the adrenal gland. V. Adenylate cyclase in the adrenal medulla.
Studies on cyclic nucleotides in the adrenal gland. V. Adenylate cyclase in the adrenal medulla.
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肾上腺环核苷酸的研究。
DOI：
10.1254/jjp.26.711
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发表时间：
1976
期刊：
影响因子：
--
通讯作者：
Kouyama
中科院分区：
文献类型：
--
作者：
S. Shima;Y. Kawashima;M. Hirai;Kouyama
本文研究了在牛肾上腺髓质片分泌过程中，引起儿茶酚胺释放的各种化学试剂对腺苷酸环化酶-环腺苷酸生成系统的影响。环磷酸腺苷水平不受影响的间隔的最大增加的儿茶酚胺释放乙酰胆碱，但逐渐增加后的释放结束后的一段时间/或在开始恢复的儿茶酚胺在髓质组织。这种延迟增加的髓质环AMP是不归因于直接参与的“刺激分泌耦合过程”的髓质分泌，而是可能是由细胞内的儿茶酚胺释放。
Effects of various chemical agents eliciting the catecholamine-release on the adenylate cyclase-cyclic AMP generating system have been studied in the secretory process of the bovine adrenal medulla slices. Cyclic AMP levels were not affected at the interval of the maximal increase of the catecholamine-release by acetylcholine, but increased gradually some time after the end of the release/or at the beginning of the restoration of catecholamine in the medulla tissue. This delayed increase in the medullary cyclic AMP is not attributed to a direct involvement in 'stimulus-secretion coupling process' of the medullary secretion, but rather may be caused by release of intracellular catecholamine.