CSF and plasma cytokines at delivery and postpartum mood disturbances
CSF and plasma cytokines at delivery and postpartum mood disturbances
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DOI：
10.1016/j.jad.2008.07.008
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发表时间：
2009-05-01
影响因子：
6.6
通讯作者：
Nikolaou, Chryssoula
中科院分区：
文献类型：
--
作者：
Boufidou, Fotini;Lambrinoudaki, Irini;Nikolaou, Chryssoula
背景资料：免疫激活已被证明参与焦虑状态和重度抑郁症的病理生理学，妊娠与维持胎儿的特征性免疫激活相关。尽管免疫参数和产后情绪障碍之间的关系的可能性，很少有研究探讨这种关联。此外，没有研究到目前为止已检查CSF.Methods：五十六希腊产妇被招募和详细的医疗和产科史记录。所有患者均完成产后忧郁问卷（入院时和产后1-4天）和爱丁堡产后抑郁量表（产后第1周和第6周）。分娩时，从33名参与者中采集血液样本和穿刺硬膜外镇痛时的CSF样本;仅从其余23名产妇中采集血液样本。TNF-α和IL-6用所有ELISA测定法定量。对依赖于细胞因子水平的心理测量分数的多元回归分析显示，细胞因子水平与产后前四天的抑郁情绪呈正相关（对于CSF IL-6，p =0.035;对于CSF TnF-a，p=0.025;对于血清TnF-a，p=0.023）和产后第六周（对于CSF IL-6，p =0.012;对于CSF TnF-a，p=0.072）。怀孕时间有不利的关联心理scores.Conclusions：免疫机制可能发挥作用的产后抑郁情绪转变的发病机制。产后母体免疫系统的“反弹”反应的作用应进一步研究。(C)2008 Elsevier B. V.保留所有权利。
Background: Immune activation has been shown to be involved in the pathophysiology of anxiety states and major depression and pregnancy is associated with a characteristic immune activation to sustain the fetus. Despite the possibility of a relation between immune parameters and postpartum mood disturbance, few studies have explored this association. Further, no study to-date has examined CSF.Methods: Fifty-six Greek parturients were recruited and a detailed medical and obstetric history was recorded. All of them completed the Postpartum Blues Questionnaire (on admission and on days 1-4 postpartum) and the Edinburgh Postnatal Depression Scale (at first and sixth week postpartum). At delivery, a blood sample and a CSF sample while puncturing for epidural analgesia were taken from 33 participants; blood samples only were obtained from the rest of the 23 parturients. TNF-a and IL-6 were quantified with ail ELISA assay.Results: A multiple regression analysis of psychometric scores depending on cytokine levels revealed that cytokine levels were positively associated with depressive mood during the first four days postpartum (p=0.035 for CSF IL-6, p=0.025 for CSF TnF-a, p=0.023 for serum TnF-a) and also at sixth week postpartum (p=0.012 for CSF IL-6, p=0.072 for CSF TnF-a). Pregnancy duration had an adverse association to psychometric scores.Conclusions: It is suggested that immune mechanisms may play a role in the etiopathology of postpartum depressive mood shifts. The role of a "rebound" reaction of the maternal immune system postnatal should be further investigated. (C) 2008 Elsevier B.V. All rights reserved.