Low 25-hydroxyvitamin D level is independently associated with non-alcoholic fatty liver disease.
Low 25-hydroxyvitamin D level is independently associated with non-alcoholic fatty liver disease.
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DOI：
10.1016/j.numecd.2012.12.006
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发表时间：
2013-08
期刊：
影响因子：
--
通讯作者：
Chonchol M
中科院分区：
文献类型：
--
作者：
Jablonski KL;Jovanovich A;Holmen J;Targher G;McFann K;Kendrick J;Chonchol M
我们试图探索美国综合医疗保健系统中血清25-羟基维生素D [25（OH）D]水平与非酒精性脂肪性肝病[NAFLD]之间的相关性。607例NAFLD病例与对照组按年龄、性别、种族和测量季节1：1随机匹配。使用条件logistic回归评估在调整体重指数和糖尿病、肾脏、外周血管和肝脏疾病史（模型1）以及高血压（模型2）后，血清25（OH）D水平是否与NAFLD（超声诊断）的几率增加相关。NAFLD组血清25（OH）D水平显著低于对照组（75±17 vs.85 ±20 nmol/L [30±7 vs.34 ±8 ng/mL]，P<0.001）。当将25（OH）D状态分类为充足（25（OH）D 75 nmol/L [>30 ng/mL]，参考组）、不足（25（OH）D>30 ng/mL）和不足（25（OH）D>30 ng/mL）时，（37-75 nmol/L [15-30 ng/mL];校正比值比[OR]：2.40，95%置信区间[CI]：0.90-6.34）或缺乏（<37 nmol/L [<15 ng/mL];校正OR：2.56，95% CI：1.27-5.19）。当作为连续变量建模时，log 10 25（OH）D增加与NAFLD流行风险呈负相关（校正OR：0. 25，95% CI：0. 064 - 0. 96，P= 0. 02）。与对照组相比，NAFLD患者血清25（OH）D水平显著降低，表明低25（OH）D状态可能在NAFLD的发生和进展中起作用。
We sought to explore associations between serum 25-hydroxyvitamin D [25(OH)D] levels and non-alcoholic fatty liver disease [NAFLD] in an integrated healthcare delivery system in the U.S. 607 NAFLD cases were randomly matched 1:1 with controls for age, sex, race and season of measurement. Conditional logistic regression was used to evaluate if serum 25(OH)D levels were associated with increased odds of NAFLD (diagnosed by ultrasound) after adjusting for body mass index and history of diabetes, renal, peripheral vascular and liver diseases (model 1) and also for hypertension (model 2). Mean (SD) serum 25(OH)D level was significantly lower in the group with NAFLD as compared with that in the matched control group (75±17 vs. 85±20 nmol/L [30±7 vs. 34±8 ng/mL], P<0.001). Inadequate 25(OH)D status progressively increased the odds of NAFLD when classified categorically as sufficient (25(OH)D 75 nmol/L [>30 ng/mL], reference group), insufficient (37–75 nmol/L [15–30 ng/mL]; adjusted odds ratio [OR]: 2.40, 95% confidence interval [CI]: 0.90–6.34) or deficient (<37 nmol/L [<15 ng/mL]; adjusted OR: 2.56, 95% CI: 1.27–5.19). When modeled as a continuous variable, increased log10 25(OH)D was inversely associated with the risk of prevalent NAFLD (adjusted OR: 0.25, 95% CI: 0.064–0.96, P=0.02). Compared with matched controls, patients with NAFLD have significantly decreased serum 25(OH)D levels, suggesting that low 25(OH)D status might play a role in the development and progression of NAFLD.
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影响因子：
7.7
作者：
Targher, G;Bertolini, L;Falezzal, G
通讯作者：
Falezzal, G
影响因子：
7.1
作者：
Schleithoff, SS;Zittermann, A;Koerfer, R
通讯作者：
Koerfer, R
影响因子：
13.5
作者：
Roth, Christian L.;Elfers, Clinton T.;Kowdley, Kris V.
通讯作者：
Kowdley, Kris V.
DOI：
10.1016/j.jsbmb.2008.12.004
发表时间：
2009-01-01
影响因子：
4.1
作者：
Suzuki, Yasuo;Ichiyama, Takashi;Furukawa, Susumu
通讯作者：
Furukawa, Susumu
影响因子：
16.2
作者：
Cigolini, M;Iagulli, MP;Targher, G
通讯作者：
Targher, G