Surgical decompression in acute spinal cord injury: A review of clinical evidence, animal model studies, and potential future directions of investigation.
Surgical decompression in acute spinal cord injury: A review of clinical evidence, animal model studies, and potential future directions of investigation.
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DOI：
10.1007/s11515-014-1297-z
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发表时间：
2014-02-01
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急性脊髓损伤（SCI）的治疗目标是减少继发性损伤的程度，促进神经再生和功能恢复。尽管多项研究已经调查了治疗急性SCI的潜在新疗法，但旨在改善患者神经损伤的结局和管理方案仍然无效。最近的临床和基础科学研究表明，手术干预是一种潜在的有价值的治疗方式;然而，手术减压的作用和时机，除了最佳的手术干预，仍然是最有争议的话题之一，有关急性SCI的手术治疗。随着越来越多的潜在治疗方式的出现，动物模型是研究其临床应用和转化为人体试验的关键。本综述批判性地评价了临床和基础科学研究的现有文献，以突出已经发生的调查范围，考虑的特定治疗方法以及未来研究的潜在领域。
The goal for treatment in acute spinal cord injury (SCI) is to reduce the extent of secondary damage and facilitate neurologic regeneration and functional recovery. Although multiple studies have investigated potential new therapies for the treatment of acute SCI, outcomes and management protocols aimed at ameliorating neurologic injury in patients remain ineffective. More recent clinical and basic science research have shown surgical interventions to be a potentially valuable modality for treatment; however, the role and timing of surgical decompression, in addition to the optimal surgical intervention, remain one of the most controversial topics pertaining to surgical treatment of acute SCI. As an increasing number of potential treatment modalities emerge, animal models are pivotal for investigating its clinical application and translation into human trials. This review critically appraises the available literature for both clinical and basic science studies to highlight the extent of investigation that has occurred, specific therapies considered, and potential areas for future research.