Normalization of T2 signal abnormalities in hemispheric white matter with liver transplant
Normalization of T2 signal abnormalities in hemispheric white matter with liver transplant
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DOI：
10.1212/wnl.59.3.335
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发表时间：
2002-08-13
期刊：
影响因子：
9.9
通讯作者：
Alonso, J
中科院分区：
文献类型：
--
作者：
Rovira, A;Córdoba, J;Alonso, J
目的：探讨MRI能否用半球白质T2加权信号强度评价肝硬变患者的脑水肿程度。方法：分别于肝移植前(24例)和肝移植后(11例)进行快速FLAIR成像和磁化传递成像。分析基线扫描T2加权异常及其时程变化，并与MT比率(MTR)进行比较。结果：FAST-FLAIR基线图像显示23/24例患者皮质脊髓束内或周围的大脑半球白质内或周围呈微弱至实质性的对称性信号增强。肝移植后信号异常逐渐恢复。这种信号强度的逐渐降低与MTR值的增加相关。结论：肝硬变患者大脑半球白质在FAST-FLAIR成像上表现为无症状的对称性高信号。在成功肝移植后，这一发现的正常化及其与MTR值的相关性表明，这一信号异常反映了轻度水肿。
Objective: To determine whether edema can be assessed by MRI using T2-weighted signal intensity of hemispheric white matter in cirrhotic patients. Methods: Fast-FLAIR and magnetization transfer images were obtained before (24) and after (11) liver transplantation. T2-weighted abnormalities on baseline scans and their time-course changes were analyzed and compared with MT ratios (MTR). Results: Fast-FLAIR baseline images showed faint to substantial, bilateral, symmetric increased signal intensity along the hemispheric white matter in or around the corticospinal tract in 23/24 patients. After liver transplantation the signal abnormalities gradually recovered. This gradual decrease in signal intensity correlated with an increase in MTR values. Conclusion: Asymptomatic symmetric high-signal intensity in the hemispheric white matter on fast-FLAIR MR images is present in cirrhosis. Normalization of this finding after successful liver transplantation and its correlation with MTR values suggest that this signal abnormality reflects mild edema.