OTOTOXIC REACTION TO ERYTHROMYCIN
OTOTOXIC REACTION TO ERYTHROMYCIN
复制标题
DOI：
10.1001/archinte.151.2.380
复制
发表时间：
1991-02-01
影响因子：
--
通讯作者：
PICADO, C
中科院分区：
文献类型：
--
作者：
AGUSTI, C;FERRAN, F;PICADO, C
我们报告了一例接受静脉注射乳糖酸红霉素治疗的患者出现双侧听力损失的病例。尽管患者的肾功能和肝功能正常，并且血清红霉素水平在预测的正常范围内，但还是发生了耳毒性反应。除了听力损失外，还观察到明显的迷路反射减弱。停止治疗后听力损失有所改善，但迷路异常持续存在，表明红霉素已造成永久性前庭损伤。
We report a case of bilateral hearing loss in a patient treated with intravenous erythromycin lactobionate. The ototoxic reaction occurred despite the patient's having normal renal and hepatic function and the fact that serum erythromycin levels were within the predicted normal range. In addition to hearing loss, a marked labyrinthic hyporreflexia was also observed. Hearing loss improved after the treatment was discontinued, but labyrinthic abnormalities persisted suggesting that erythromycin had caused a permanent vestibular damage.