Brain MRI hippocampal of clinical status in a mild volume and prediction cognitive impairment trial
Brain MRI hippocampal of clinical status in a mild volume and prediction cognitive impairment trial
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DOI：
10.1007/s12031-002-0006-6
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发表时间：
2002-08-01
影响因子：
3.1
通讯作者：
Thal, LJ
中科院分区：
文献类型：
--
作者：
Grundman, M;Sencakova, D;Thal, LJ
轻度认知障碍(MCI)被认为是阿尔茨海默病发病机制的一个过渡阶段；然而，并不是所有的MCI患者都进展到临床定义的AD或以相同的速度下降。根据磁共振成像(MRI)的测量，海马区萎缩可能是MCI患者海马区病理的一个标志，并预示着更快地恶化为临床AD。在这项研究中，我们使用了一项正在进行的MCI临床试验的MRI数据，以确定基线时MRI海马体体积是否与MCI受试者的认知和功能表现有关，以及它是否可以预测更有可能发展为AD的个体。我们在研究开始时进行了MRI海马体体积与受试者同时进行的神经心理测量和临床评分之间的相关性分析。海马体体积越大，在记忆力、一般认知和总体临床评级测试中的表现越好。进一步的分析表明，基线海马体体积较小可能与发生临床AD的风险较高有关。由于审判仍在进行中，这些结果需要在审判完成后予以确认。综上所述，这些数据表明，MRI海马体体积可能是MCI受试者疾病严重程度的有用相关性，并可作为预测后续AD的指标。
Mild Cognitive Impairment (MCI) is considered a transitional stage in the pathogenesis of Alzheimer's disease; however, not all MCI patients progress to clinically defined AD or decline at identical rates. Hippocampal atrophy, as measured by Magnetic Resonance Imaging (MRI), may be a marker for hippocampal pathology in patients with MCI and predict a more rapid deterioration to clinical AD. In this study, we used MRI data from an ongoing MCI clinical trial to determine whether MRI hippocampal volume at baseline was associated with cognitive and functional performance in MCI subjects and whether it predicted those individuals who were more likely to develop AD. We performed correlational analyses between the MRI hippocampal volumes at study entry and the subjects' concurrent performance on neuropsychological measures and clinical ratings. Larger hippocampal volume was associated with better performance on tests of memory, general cognition, and overall clinical ratings. Further analyses suggested that a smaller baseline hippocampal volume may be associated with a higher risk of developing clinical AD. As the trial is still ongoing, these results require confirmation once the trial is completed. In summary, these data suggest that MRI hippocampal volume may be a useful correlate of disease severity in MCI subjects and a prognostic indicator of subsequent AD.