Stabilization of Cox1p intermediates by the Cox14p-Coa3p complex.
Stabilization of Cox1p intermediates by the Cox14p-Coa3p complex.
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Cox14p-Coa3p 复合物对 Cox1p 中间体的稳定作用。
DOI：
10.1016/j.febslet.2013.02.022
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发表时间：
2013
期刊：
影响因子：
3.5
通讯作者：
Tzagoloff,Alexander
中科院分区：
文献类型：
--
作者：
McStay,GavinP;Su,ChenHsien;Tzagoloff,Alexander
Cox14 p和Coa3p已被证明调节线粒体COX1 mRNA的翻译，并且是细胞色素氧化酶组装所需的。我们目前的证据表明，Cox14 p和Coa3p稳定以前确定的Cox1p中间体，并在没有任何蛋白质，Cox1p与自身和其他线粒体基因产物，包括细胞色素B，Var1p和Cox2p的聚集。我们的证据表明，Cox1p组装中间体是在密切接近其他翻译的蛋白质和Cox14 p和Coa3p的一个重要功能是防止Cox1进入非生产性聚集途径。
Cox14p and Coa3p have been shown to regulate translation of the mitochondrial COX1 mRNA and to be required for assembly of cytochrome oxidase. We present evidence that Cox14p and Coa3p stabilize previously identified Cox1p intermediates and that in the absence of either protein, Cox1p aggregates with itself and other mitochondrial gene products, including cytochrome b, Var1p and Cox2p. Our evidence suggests that Cox1p assembly intermediates are in close proximity to other mitochondrially translated proteins and that an important function of Cox14p and Coa3p is to prevent Cox1 from entering into unproductive aggregation pathways.