Flexibility and lengths of bis-peptide nanostructures by electron spin resonance.
Flexibility and lengths of bis-peptide nanostructures by electron spin resonance.
复制标题
通过电子自旋共振研究双肽纳米结构的灵活性和长度。
DOI：
10.1021/ja058143e
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发表时间：
2006
影响因子：
15
通讯作者：
Saxena,Sunil
中科院分区：
文献类型：
--
作者：
Pornsuwan,Soraya;Bird,Gregory;Schafmeister,ChristianE;Saxena,Sunil
我们演示了使用电子自旋共振（ESR）来确定水溶性双肽分子棒的长程距离和灵活性。合成了具有4−8个单体单元的二肽低聚物。ESR确定肽的端到端长度与单体的数量成线性比例。因此，线性形状很容易从数据中解释。此外，从ESR确定的距离分布函数直接量化杆的灵活性。链长和灵活性的定量信息是重要的，开发使用这些低聚物作为棒状结构元素的应用，如配体的二价显示和作为未来的纳米器件的元素。
We demonstrate the use of electron spin resonance (ESR) to determine long-range distances and flexibility in water-soluble bis-peptide molecular rods. Bis-peptide oligomers with 4−8 monomer units were synthesized. ESR determined that the end-to-end length of the peptides is linearly proportional to the number of monomers. The linear shape is, therefore, easily interpreted from the data. In addition, the flexibility of the rods was quantified directly from the ESR-determined distance distribution functions. Quantitative information on chain length and flexibility is important to develop the use of these oligomers as rodlike structural elements for applications such as bivalent display of ligands and as elements of future nanoscale devices.