Animal Models of Nonalcoholic Fatty Liver Disease-A Starter's Guide.
Animal Models of Nonalcoholic Fatty Liver Disease-A Starter's Guide.
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DOI：
10.3390/nu9101072
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发表时间：
2017-09-27
期刊：
影响因子：
5.9
通讯作者：
Francque SM
中科院分区：
文献类型：
--
作者：
Van Herck MA;Vonghia L;Francque SM
非酒精性脂肪性肝病(NAFLD)是一个主要的健康问题，在许多西方国家，肥胖症和糖尿病的发病率不断上升，在普通人群中的患病率高达30%。动物模型在阐明NAFLD的病理生理机制方面发挥了至关重要的作用，并将继续这样做。存在着无数种不同的模式，每种模式都有其优缺点。本文就这些模型的基本机制、物理、生化和组织学表型作一简要综述。研究了营养和化学诱导以及遗传模型，包括结合不同方法的模型。
Nonalcoholic fatty liver disease (NAFLD) constitutes a major health concern with the increasing incidence of obesity and diabetes in many Western countries, reaching a prevalence of up to 30% in the general population. Animal models have played a vital role in elucidating the pathophysiological mechanisms of NAFLD and continue to do so. A myriad of different models exists, each with its advantages and disadvantages. This review presents a brief overview of these models with a particular focus on the basic mechanisms and physical, biochemical and histological phenotype. Both nutritional and chemically induced, as well as genetic models are examined, including models combining different approaches.