EFFECTS OF NALTREXONE ON LEARNING AND PERFORMANCE OF CONDITIONAL FEAR-INDUCED FREEZING AND OPIOID ANALGESIA
EFFECTS OF NALTREXONE ON LEARNING AND PERFORMANCE OF CONDITIONAL FEAR-INDUCED FREEZING AND OPIOID ANALGESIA
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DOI：
10.1016/0031-9384(87)90380-5
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发表时间：
1987-01-01
影响因子：
2.9
通讯作者：
FANSELOW, MS
中科院分区：
文献类型：
--
作者：
HELMSTETTER, FJ;FANSELOW, MS
在巴甫洛夫条件厌恶刺激的存在下，大鼠进行防御性冻结，并表现出对疼痛刺激的敏感性下降。阿片类药物拮抗剂纳洛酮（7毫克/毫升/公斤）的背景下恐惧条件反射程序使用足电击训练前的管理引起增加冻结，但不影响抑制福尔马林诱导的恢复性行为相对于对照组在测试会议24小时后。在测试过程中给予相同剂量的纳洛酮逆转了条件性镇痛，而没有改变冷冻水平。这些结果表明，在训练过程中内源性阿片镇痛的充分表达是不必要的条件反应。
In the presence of Pavlovian conditional aversive stimuli rats engage in defensive freezing and exhibit a decreased sensitivity to painful stimulation. Administration of the opioid antagonist naltrexone (7 mg/ml/kg) prior to training in a context fear conditioning procedure using footshock caused an increase in freezing but did not affect suppression of formalin-induced recuperative behaviours relative to controls during a test session 24 hr later. The same dose of naltrexone given during the test session reversed conditional analgesia without altering the level of freezing. These results suggest that full expression of endogenous opioid analgesia during training is not necessary for conditional responding.