Excess tau PET ligand retention in elderly patients with major depressive disorder
Excess tau PET ligand retention in elderly patients with major depressive disorder
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DOI：
10.1038/s41380-020-0766-9
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发表时间：
2020-07-01
影响因子：
11
通讯作者：
Higuchi, Makoto
中科院分区：
文献类型：
--
作者：
Moriguchi, Sho;Takahata, Keisuke;Higuchi, Makoto
抑郁症是老年人常见的精神疾病之一。重度抑郁障碍（MDD）已被确定为神经退行性痴呆的危险因素或前驱症状，表明MDD和神经退行性疾病之间存在神经病理重叠和连续体。在这项研究中，我们使用正电子发射断层扫描（PET）检测了MDD患者和健康对照者大脑中tau和β淀粉样蛋白（A β）的积累，以探索这种疾病的病理基础。20名MDD患者和20名年龄匹配的健康对照者通过PET检测tau放射性配体[C-11]PBB3和a β放射性配体[C-11]PiB。放射性配体保留量被量化为标准摄取值比（SUVR）。我们还使用17项汉密尔顿抑郁量表、老年抑郁量表和精神病症状来评估患者的临床表现。MDD患者平均皮质[C-11]PBB3 SUVRs显著高于健康对照组。这些值在有精神病症状的重度抑郁症患者中高于无精神病症状的患者。目前的研究结果表明，tau沉积可能是重度抑郁症的基础，特别是在有精神病症状的患者中。PET检测tau积聚可能为这些病例的神经元功能障碍提供机制见解，并可作为其临床后果的预测。
Depression is one of the common psychiatric disorders in old age. Major depressive disorder (MDD) has been identified as a risk factor or prodrome for neurodegenerative dementias, suggesting neuropathological overlaps and a continuum between MDD and neurodegenerative disorders. In this study, we examined tau and amyloid-beta (A beta) accumulations in the brains of MDD and healthy controls using positron emission tomography (PET) to explore pathological substrates of this illness. Twenty MDD and twenty age-matched, healthy controls were examined by PET with a tau radioligand, [C-11]PBB3, and an A beta radioligand, [C-11]PiB. Radioligand retentions were quantified as a standardized uptake value ratio (SUVR). We also assessed clinical manifestations of the patients using the 17-item Hamilton Depression Scale, the Geriatric Depression Scale, and psychotic symptoms. Mean cortical [C-11]PBB3 SUVRs in MDD patients were significantly higher than those of healthy controls. These values were higher in MDD patients with psychotic symptoms than in those without any. The present findings indicate that tau depositions may underlie MDD, and especially in patients with psychotic symptoms. PET detection of tau accumulations may provide mechanistic insights into neuronal dysfunctions in these cases and could serve as predictions of their clinical consequences.