Binding affinities of 438 HLA proteins to complete proteomes of seven pandemic viruses and distributions of strongest and weakest HLA peptide binders in populations worldwide
Binding affinities of 438 HLA proteins to complete proteomes of seven pandemic viruses and distributions of strongest and weakest HLA peptide binders in populations worldwide
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DOI：
10.1111/tan.13956
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发表时间：
2020-06-11
期刊：
影响因子：
8
通讯作者：
Sanchez-Mazas, Alicia
中科院分区：
文献类型：
--
作者：
Barquera, Rodrigo;Collen, Evelyn;Sanchez-Mazas, Alicia
我们报道了包括冠状病毒、流感病毒和HIV-1在内的7种人类大流行病毒的完整蛋白质组和438个人类白细胞抗原I类和II类蛋白之间的详细的多肽结合亲和力。我们将这些亲和力与全球数百个人类群体的人类白细胞抗原等位基因频率进行了对比。统计模型显示，分成四个不同类别的肽结合亲和力取决于人类白细胞抗原基因座，但病毒类型只是一个微弱的预测因子，除了艾滋病毒-1的情况。在强大的人类白细胞抗原结合体(IC50)中
We report detailed peptide-binding affinities between 438 HLA Class I and Class II proteins and complete proteomes of seven pandemic human viruses, including coronaviruses, influenza viruses and HIV-1. We contrast these affinities with HLA allele frequencies across hundreds of human populations worldwide. Statistical modelling shows that peptide-binding affinities classified into four distinct categories depend on the HLA locus but that the type of virus is only a weak predictor, except in the case of HIV-1. Among the strong HLA binders (IC50