Role of reactive aldehyde in cardiovascular diseases
Role of reactive aldehyde in cardiovascular diseases
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DOI：
10.1016/s0891-5849(00)00226-4
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发表时间：
2000-06-15
影响因子：
7.4
通讯作者：
Uchida, K
中科院分区：
文献类型：
--
作者：
Uchida, K
越来越多的证据表明，在生物分子降解过程中内源性产生的醛参与了许多与心血管疾病（如动脉粥样硬化和糖尿病的长期并发症）相关的病理生理过程。体内活性醛的主要来源是脂质过氧化、糖基化和氨基酸氧化。虽然醛的类型多种多样，但能够发挥与氧化损伤病理生物学相关的生物学作用的重要醛以2-烯醛、4-羟基-2-烯醛和酮醛为代表。这些醛表现出与蛋白质的易反应性，在一系列反应结束时产生稳定的产物。蛋白结合醛不仅可以在体外氧化低密度脂蛋白中检测到，而且可以在动脉粥样硬化动物模型和动脉粥样硬化危险因素增加或临床表现增加的人类患者中检测到，表明它们确实可能参与心血管病理。另一方面，许多活性醛被认为是诱导细胞内氧化应激和应激信号通路激活的诱导剂，与其他信号通路结合，控制细胞对细胞外刺激的反应。(C) 2000 Elsevier Science Inc.；
There is increasing evidence that aldehydes generated endogenously during the degradation process of biological molecules are involved in many of the pathophysiologies associated with cardiovasular diseases such as atherosclerosis and the long-term complications of diabetes. Major sources of reactive aldehydes in vivo are lipid peroxidation, glycation, and amino acid oxidation. Although the types of aldehydes are varied, the important aldehydes that can exert biological effects relevant to the pathobiology of oxidant injury are represented by 2-alkenals, 4-hydroxy-2-alkenals, and ketoaldehydes. These aldehydes exhibit facile reactivity with proteins, generating stable products at the end of a series of reactions. The protein-bound aldehydes can be detected as constituents not only in in vitro oxidized low-density lipoproteins but also in animal models of atherosclerosis and in human patients with increased risk factors or clinical manifestations of atherosclerosis, indicating that they could indeed be involved in the caldiovascular pathology. On the other hand, a number of reactive aldehydes have been implicated as inducers in generating intracellular oxidative stress and activation of stress signaling pathways, that integrate with other signaling pathways to control cellular responses to the extracellular stimuli. (C) 2000 Elsevier Science Inc.