Body composition and endocrine status of long-term stress-induced binge-eating rats
Body composition and endocrine status of long-term stress-induced binge-eating rats
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DOI：
10.1016/j.physbeh.2007.04.001
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发表时间：
2007-07-24
影响因子：
2.9
通讯作者：
Boggiano, M. M.
中科院分区：
文献类型：
--
作者：
Artiga, A. I.;Viana, J. B.;Boggiano, M. M.
临床上的暴饮暴食是一个长期的过程。暴饮暴食的病因仍然令人困惑，部分原因是，在人类中，很难分离和评估各种影响变量的独立和综合影响。使用大鼠，我们发现足电击应激和热量限制（S + R）的历史，联合收割机协同诱导暴食。压力和节食也是人类饮食失调的重要前因和复发因素。在这里，我们报告进一步的行为和生理相似之处，人类暴食。与人类长期暴饮暴食一样，年轻的雌性Sprague-Dawley大鼠在23个限制/应激周期（7个月）后继续暴饮暴食，尽管在限制阶段没有显著的体重减轻。压力本身减少了35%的肥胖（p
Clinical binge eating runs a protracted course. The etiology of binge eating remains perplexing in part because, in humans, it is difficult to isolate and assess the independent and aggregate impact of various contributing variables. Using rats, we found that footshock stress and a history of caloric restriction (S+R), combine synergistically to induce binge eating. Stress and dieting are also strong antecedents and relapse factors in human eating disorders. Here we report further behavioral and physiological parallels to human binge eating. Like the protracted course of human binge eating, young female Sprague-Dawley rats continued to binge eat after 23 restriction/stress cycles (7 months) and this despite experiencing no significant weight loss during the restriction phases. Stress alone reduced adiposity by 35% (p