Race, breast cancer subtypes, and survival in the Carolina Breast Cancer Study
Race, breast cancer subtypes, and survival in the Carolina Breast Cancer Study
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DOI：
10.1001/jama.295.21.2492
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发表时间：
2006-06-07
影响因子：
120.7
通讯作者：
Millikan, Robert C.
中科院分区：
文献类型：
--
作者：
Carey, Lisa A.;Perou, Charles M.;Millikan, Robert C.
基因表达分析已经确定了几种乳腺癌亚型，包括基底样、人表皮生长因子受体2阳性/雌激素受体阴性（HER 2 +/ER-）、管腔A和管腔B。目的确定乳腺癌亚型的基于人群的分布和临床相关性。设计，设置，研究人员对来自卡罗莱纳乳腺癌研究的496例浸润性乳腺癌病例进行了免疫组化检测，（1993年5月至1996年12月期间确定），一项基于人群的病例对照研究，对绝经前和非洲裔美国妇女进行了过采样。亚型定义如下：管腔A（ER +和/或孕酮受体阳性[PR+]，HER 2-），管腔B（ER +和/或PR +，HER 2+），基底细胞样（ER-、PR-、HER 2-、细胞角蛋白5/6阳性和/或HER 1+）、HER 2 +/ ER-（ER-、PR-和HER 2+）和未分类（所有5种标记均为阴性）。主要结果测量我们检查了乳腺癌亚型在种族和绝经期亚群中的患病率，并确定了它们与肿瘤大小，腋窝淋巴结状态，结果基底细胞样乳腺癌亚型在绝经前非裔美国妇女（39%）中的患病率高于绝经后非裔美国妇女（14%）和非裔美国妇女（16%）（P
Context Gene expression analysis has identified several breast cancer subtypes, including basal-like, human epidermal growth factor receptor-2 positive/estrogen receptor negative (HER2+/ER-), luminal A, and luminal B.Objectives To determine population-based distributions and clinical associations for breast cancer subtypes.Design, Setting, and Participants Immunohistochemical surrogates for each subtype were applied to 496 incident cases of invasive breast cancer from the Carolina Breast Cancer Study ( ascertained between May 1993 and December 1996), a population-based, case-control study that oversampled premenopausal and African American women. Subtype definitions were as follows: luminal A ( ER + and/or progesterone receptor positive [PR+], HER2-), luminal B ( ER + and/or PR +, HER2+), basal-like (ER-, PR-, HER2-, cytokeratin 5/6 positive, and/or HER1+), HER2+/ ER- ( ER-, PR-, and HER2+), and unclassified ( negative for all 5 markers).Main Outcome Measures We examined the prevalence of breast cancer subtypes within racial and menopausal subsets and determined their associations with tumor size, axillary nodal status, mitotic index, nuclear pleomorphism, combined grade, p53 mutation status, and breast cancer - specific survival.Results The basal-like breast cancer subtype was more prevalent among premenopausal African American women (39%) compared with postmenopausal African American women (14%) and non - African American women (16%) of any age ( P