Metformin for the treatment of the polycystic ovary syndrome.
Metformin for the treatment of the polycystic ovary syndrome.
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DOI：
10.1097/00006250-200304000-00029
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发表时间：
2004-02
影响因子：
1
通讯作者：
R. Barbieri;A. Gargiulo
中科院分区：
文献类型：
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作者：
R. Barbieri;A. Gargiulo
多囊卵巢综合征（PCOS）的特征是LH、胰岛素和雄激素分泌增加。多囊卵巢综合征的主要临床症状包括：少经或闭经、功能失调性子宫出血、多毛症、肥胖和/或无排卵性不孕。这些问题的一线治疗包括：1）用于月经过少和功能失调性子宫出血的雌激素-孕酮治疗; 2）用于多毛症的雌激素-孕酮治疗和/或抗雄激素治疗; 3）用于肥胖症的生活方式改变，如饮食和锻炼;和4）用于无排卵性不孕症的体重减轻或克罗米芬。然而，临床试验表明，当一线治疗无效、患者不可接受或医学禁忌时，二甲双胍是有效的二线治疗。将二甲双胍添加到妇科内分泌医生的医疗设备中代表了一个重要的进步。
The polycystic ovary syndrome (PCOS) is characterized by increased secretion of LH, insulin and androgens. The main clinical complaints of women with PCOS include: oligo- or amenorrhea, dysfunctional uterine bleeding, hirsutism, obesity and/or anovulatory infertility. The first line treatment for these problems include: 1) estrogen-progestin therapy for oligomenorrhea and dysfunctional uterine bleeding; 2) estrogen-progestin therapy and/or antiandrogens for hirsutism; 3) lifestyle changes such as diet and exercise for obesity and 4) weight loss or clomiphene for anovulatory infertility. However, clinical trials have indicated that metformin is effective second line therapy when first line therapy has not been effective, is not acceptable to the patient or is medically contraindicated. The addition of metformin to the armamentarium of the gynecological endocrinologist represents an important advance.