Apathy, depression, and cognitive performance in HIV-1 infection
Apathy, depression, and cognitive performance in HIV-1 infection
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DOI：
10.1176/jnp.10.3.320
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发表时间：
1998-06-01
影响因子：
2.9
通讯作者：
Yarema, KT
中科院分区：
文献类型：
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作者：
Castellon, SA;Hinkin, CH;Yarema, KT
作者采用反应时和工作记忆任务，对48名HIV-1阳性者和21名阴性者（对照组）的冷漠、抑郁和认知能力之间的关系进行了研究。冷漠，而不是抑郁症，与工作记忆缺陷之间的艾滋病毒血清阳性受试者。贝克抑郁量表（BDI）的认知情感成分，不是冷漠，与选择RT任务的准确性降低和降低有关。BDI认知情感成分比BDI躯体成分与RT减慢和冷漠更密切相关。结果表明，冷漠的突出症状，独立的抑郁症，可能是中枢神经系统参与HIV感染的一个重要指标。总BDI分数显示出不太一致的关系与神经认知性能，这表明，体细胞神经病学是诊断模糊的HIV感染者。
The authors examined the relationship between apathy, depression, ann cognitive performance in 48 HIV-1-seropositive and 21 seronegative (control) subjects, using reaction time (RT) and working memory tasks. Apathy, but not depression, was associated with working memory deficits among HIV-seropositive subjects. The cognitive-affective component of the Beck Depression Inventory (BDI), bit not apathy was associated with slowing and decreased accuracy on a choice RT task. The BDI cognitive-affective component was more closely associated than the BDI somatic component with both RT slowing and apathy. Results suggest that prominent symptoms of apathy, independent of depression, may be an important indicator of CNS involvement in HIV infection. Total BDI scores showed a less consistent relationship with neurocognitive performance, suggesting that somatic symptomatology is diagnostically ambiguous among HIV-infected subjects.