A dispersion model of hepatic elimination: 1. Formulation of the model and bolus considerations
A dispersion model of hepatic elimination: 1. Formulation of the model and bolus considerations
复制标题
肝脏消除的分散模型： 1. 模型的制定和推注注意事项
DOI：
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发表时间：
1986
期刊：
影响因子：
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通讯作者：
M. Rowland
中科院分区：
文献类型：
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作者：
M. Roberts;M. Rowland
基于血液元素在肝脏中的滞留时间分布，提出了一个肝脏消除的弥散模型。导出了适用于描述示踪剂溶质肝脏输出浓度的一般速率方程。特别考虑了示踪剂团注输入剂量后发生的事件。该模型与已知的肝脏结构和肝脏生理特征相一致。该模型已适用于红血球、白蛋白和其他未消除的溶质的肝脏流出数据。实验数据表明，血液元素在肝脏中的分散程度很高。该模型还被用来评估酶活性、肝细胞通透性、血流和蛋白质结合的变化对溶质流出浓度随时间分布的影响。
A dispersion model of hepatic elimination, based on the residence time distribution of blood elements within the liver, is presented. The general rate equations appropriate for describing the hepatic output concentration of a tracer solute are derived. Particular consideration is given to events following a bolus input dose of a tracer. The model is shown to be compatible with the known hepatic architecture and hepatic physiology. The model has been fitted to hepatic outflow data for red blood cells, albumin, and other noneliminated solutes. The experimental data suggest a high degree of dispersion of blood elements within the liver. The model has also been used to evaluate the effects of changes in enzyme activity, hepatic cell permeability, blood flow, and protein binding on the outflow concentration vs. time profiles of solutes.