Simultaneous cortical, subcortical, and brainstem mapping of sensory activation.
Simultaneous cortical, subcortical, and brainstem mapping of sensory activation.
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感觉激活的同步皮质、皮质下和脑干绘图。
DOI：
10.1101/2024.04.11.589099
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发表时间：
2024
期刊：
影响因子：
--
通讯作者：
Bright,MollyG
中科院分区：
文献类型：
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作者：
Reddy,NehaA;Clements,RebeccaG;Brooks,JonathanCW;Bright,MollyG
非疼痛性触觉刺激在皮层、皮层下和脑干中进行处理。最近的功能性磁共振成像研究强调了全脑，系统水平的调查检查感觉处理的价值。然而，全脑功能磁共振成像研究并不常见，部分原因是研究脑干时面临信噪比的挑战。此外，小的感觉脑干结构，如楔状核和薄束核的分化需要高分辨率成像。为了解决系统级感觉研究中的这一差距，我们采用了3T全脑多回波功能磁共振成像采集，并采用多回波独立成分分析去噪和脑干特异性建模，以检测整个感觉系统的激活。在健康受试者中，我们检查了对右手、左手和右脚（每个位置n= 10）的无痛刷牙的活动模式，并发现了预期的偏侧化，对上肢和下肢刺激具有不同的皮质和皮质下反应。在脑干水平，我们区分了邻近的楔束核和薄束核，分别对应于手和脚刺激。我们的研究结果表明，同时在3T的皮质，皮质下和脑干映射可能是一个关键的工具，以了解健康的个人和临床队列的感觉系统与感觉缺陷。
Nonpainful tactile sensory stimuli are processed in the cortex, subcortex, and brainstem. Recent functional magnetic resonance imaging studies have highlighted the value of whole-brain, systems-level investigation for examining sensory processing. However, whole-brain functional magnetic resonance imaging studies are uncommon, in part due to challenges with signal to noise when studying the brainstem. Furthermore, differentiation of small sensory brainstem structures such as the cuneate and gracile nuclei necessitates high-resolution imaging. To address this gap in systems-level sensory investigation, we employed a whole-brain, multi-echo functional magnetic resonance imaging acquisition at 3T with multi-echo independent component analysis denoising and brainstem-specific modeling to enable detection of activation across the entire sensory system. In healthy participants, we examined patterns of activity in response to nonpainful brushing of the right hand, left hand, and right foot (n= 10 per location), and found the expected lateralization, with distinct cortical and subcortical responses for upper and lower limb stimulation. At the brainstem level, we differentiated the adjacent cuneate and gracile nuclei, corresponding to hand and foot stimulation respectively. Our findings demonstrate that simultaneous cortical, subcortical, and brainstem mapping at 3T could be a key tool to understand the sensory system in both healthy individuals and clinical cohorts with sensory deficits.