THE PENTOSE-PHOSPHATE CYCLE IS REGULATED BY NADPH NADP RATIO IN RAT-LIVER
THE PENTOSE-PHOSPHATE CYCLE IS REGULATED BY NADPH NADP RATIO IN RAT-LIVER
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DOI：
10.1016/0003-9861(85)90610-1
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发表时间：
1985-01-01
影响因子：
3.9
通讯作者：
MACHADO, A
中科院分区：
文献类型：
--
作者：
FABREGAT, I;VITORICA, J;MACHADO, A
研究了不同 NADPH 消耗途径的激活或抑制所产生的戊糖磷酸循环活性的变化。犬尿酸盐对脂肪酸合成的抑制产生相同程度的磷酸戊糖循环活性的抑制以及NADPH/NADP比率的增加（约2倍）。添加叔丁基氢过氧化物或百草枯（通过 NADPH 消耗途径代谢）会激活戊糖磷酸循环，并降低 NADPH/NADP 比率（约 3 倍）。 NADPH/NADP 比率与磷酸戊糖循环活性的关系图给出了一条回归指数为 0.999 的直线。讨论了主要通过细胞内 NADPH/NADP 比率对戊糖磷酸循环的调节。
The changes in the activity of the pentose phosphate cycle produced by the activation or inhibition of different NADPH-consuming pathways were studied. The inhibition of fatty acid synthesis by kynurenate produced to the same extent, inhibition of the pentose phosphate cycle activity and an increase (about 2-fold) in the NADPH/NADP ratio. The addition of tert-butylhydroperoxide or paraquat, which is metabolized via NADPH-consuming pathways, produced the activation of the pentose phosphate cycle and a decrease in the NADPH/NADP ratio (about 3-fold). The plot of the NADPH/NADP ratio vs. the pentose phosphate cycle activity gave a straight line with a regression index of 0.999. The regulation of the pentose phosphate cycle mainly by the intracellular NADPH/NADP ratio is discussed.