Inflammatory signalings involved in airway and pulmonary diseases.
Inflammatory signalings involved in airway and pulmonary diseases.
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DOI：
10.1155/2013/791231
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发表时间：
2013
影响因子：
4.6
通讯作者：
Yang CM
中科院分区：
文献类型：
--
作者：
Lee IT;Yang CM
在呼吸道疾病中，呼吸道中多种炎症蛋白的表达增加，包括细胞因子、趋化因子和粘附分子。趋化因子已被证明可以调节炎症和免疫细胞分化。此外，许多已知的炎症靶蛋白，如基质金属蛋白酶-9 （MMP-9）、细胞间粘附分子-1 （ICAM-1）、血管细胞粘附分子-1 （VCAM-1）、环氧化酶-2 （COX-2）和细胞质磷脂酶A2 (cPLA2)，在各种刺激下与气道和肺部炎症有关。有害的环境刺激可通过气道或肺循环和体循环进入肺。驻留细胞和循环细胞反应的时间过程和强度可能受到各种炎症信号的调节，包括Src家族激酶（SFKs）、蛋白激酶C （PKC）、生长因子酪氨酸激酶受体、烟酰胺腺嘌呤二核苷酸磷酸(NADPH)/活性氧（ROS）、PI3K/Akt、MAPKs、核因子κB （NF-κB）、激活蛋白1 （AP-1）和其他信号分子。这些信号分子调节气道和肺部炎症的关键炎症信号转导途径和靶蛋白。在此，我们讨论了与呼吸系统疾病相关的炎症靶蛋白表达的机制。对炎症调节机制的了解有助于对呼吸系统疾病的抗炎药物进行药理学操作。
In respiratory diseases, there is an increased expression of multiple inflammatory proteins in the respiratory tract, including cytokines, chemokines, and adhesion molecules. Chemokines have been shown to regulate inflammation and immune cell differentiation. Moreover, many of the known inflammatory target proteins, such as matrix metalloproteinase-9 (MMP-9), intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), cyclooxygenase-2 (COX-2), and cytosolic phospholipase A2 (cPLA2), are associated with airway and lung inflammation in response to various stimuli. Injuriously environmental stimuli can access the lung through either the airways or the pulmonary and systemic circulations. The time course and intensity of responses by resident and circulating cells may be regulated by various inflammatory signalings, including Src family kinases (SFKs), protein kinase C (PKC), growth factor tyrosine kinase receptors, nicotinamide adenine dinucleotide phosphate (NADPH)/reactive oxygen species (ROS), PI3K/Akt, MAPKs, nuclear factor-kappa B (NF-κB), activator protein-1 (AP-1), and other signaling molecules. These signaling molecules regulate both key inflammatory signaling transduction pathways and target proteins involved in airway and lung inflammation. Here, we discuss the mechanisms involved in the expression of inflammatory target proteins associated with the respiratory diseases. Knowledge of the mechanisms of inflammation regulation could lead to the pharmacological manipulation of anti-inflammatory drugs in the respiratory diseases.
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