Effects of omega-3 fatty acid supplementation on mood and emotional information processing in recovered depressed individuals
Effects of omega-3 fatty acid supplementation on mood and emotional information processing in recovered depressed individuals
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DOI：
10.1177/0269881111424928
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发表时间：
2012-05-01
影响因子：
4.1
通讯作者：
Van der Does, A. J. Willem
中科院分区：
文献类型：
--
作者：
Antypa, Niki;Smelt, August H. M.;Van der Does, A. J. Willem
据报道，omega-3脂肪酸对几种精神疾病，特别是抑郁症有有益的作用。相关研究表明，摄入omega-3脂肪酸与患抑郁症风险之间存在关联。临床试验的荟萃分析显示，补充剂对抑郁症状有中等效果，但对正常情绪状态没有效果。很少有研究调查对认知的影响。这项研究的目的是检查omega-3补充剂对恢复抑郁症患者的认知和情绪的影响。在随机双盲设计中，71名参与者随机接受omega-3或安慰剂治疗四周。结果显示，omega-3补充剂对情绪决策和自我报告的抑郁和紧张状态的影响很小。其中一些效应与学习效应相混淆。在记忆力、注意力、认知反应性和抑郁症状方面没有观察到明显的影响。虽然尚无定论，但目前的研究结果可能表明，omega-3补充剂对恢复的抑郁症参与者的情绪认知和情绪有选择性的影响。
Beneficial effects of omega-3 fatty acids have been reported for several psychiatric disorders, particularly for depression. Association studies show a relationship between omega-3 intake and depression risk. Meta-analyses of clinical trials have shown a moderate effect of supplementation on depressive symptoms, but not on normal mood states. Few studies have investigated effects on cognition. The purpose of this study was to examine effects of omega-3 supplements on cognition and mood of recovered depressed individuals. Seventy-one participants were randomized to receive either omega-3 or placebo for four weeks in a randomized double-blind design. Results showed small effects of omega-3 supplementation on aspects of emotional decision-making and on self-reported states of depression and tension. Some of the effects were confounded by learning effects. No significant effects were observed on memory, attention, cognitive reactivity and depressive symptoms. While inconclusive, the present findings may indicate that omega-3 supplementation has selective effects on emotional cognition and mood in recovered depressed participants.