Immunologic Competence of the Immature Human Fetus: Morphologic Evidence From Intrauterine Cytomegalovirus Infection
Immunologic Competence of the Immature Human Fetus: Morphologic Evidence From Intrauterine Cytomegalovirus Infection
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未成熟人类胎儿的免疫能力：宫内巨细胞病毒感染的形态学证据
DOI：
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发表时间：
1974
影响因子：
7.2
通讯作者：
G. Altshuler
中科院分区：
文献类型：
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作者：
G. Altshuler
首次提供形态学证据表明人类胎儿能够在妊娠前三个月内对传染原产生免疫反应。报告一例妊娠 13 周自然流产的病例报告。突出的病理学发现是胎盘浆细胞和绒毛炎，以及在 10 厘米头臀长男性胎儿的胎盘和各种器官中的大量巨细胞病毒包涵体。胎盘浆细胞的存在证明了胎儿对巨细胞病毒感染的免疫反应。
For the first time, morphologic evidence is provided that the human fetus is capable of immunologic response to an infectious agent within the first trimester of gestation. A case report of a spontaneous abortion at 13 weeks' gestation is presented. Outstanding pathologic findings were placental plasma cells and villitis, and numerous cytomegalovirus inclusions, in both the placenta and various organs of the 10-cm crown-rump length male fetus. Immunologic response to cytomegalovirus infection of the fetus is evidenced by the presence of placental plasma cells.