Efficient cross-coupling of functionalized arylzinc halides catalyzed by a nickel chloride-diethyl phosphite system
Efficient cross-coupling of functionalized arylzinc halides catalyzed by a nickel chloride-diethyl phosphite system
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DOI：
10.1021/ol051615
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发表时间：
2005-10-27
期刊：
影响因子：
5.2
通讯作者：
Knochel, P
中科院分区：
文献类型：
--
作者：
Gavryushin, A;Kofink, C;Knochel, P
亚磷酸二乙酯和DMAP作为镍的配体在8：1 THF-N-乙基吡咯烷酮（NEP）混合物中的组合允许在各种官能化的芳基卤化锌和芳基溴化物、三氟甲磺酸酯和活化的氯化物之间进行非常有效的交叉偶联反应。反应在25 ℃下进行1-48小时，仅需要0.05mol%的镍催化剂。
[GRAPHICS]The combination of diethyl phosphite and DMAP as ligands for nickel in an 8:1 THF-N-ethylpyrrolidinone (NEP) mixture allows a very efficient cross-coupling reaction to be performed between various functionalized arylzinc halides and aryl bromides, triflates and activated chlorides. The reaction proceeds at 25 degrees C within 1-48 h and requires only 0.05 mol % of the nickel catalyst.