Airborne Transmission of Bordetella pertussis
Airborne Transmission of Bordetella pertussis
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DOI：
10.1093/infdis/jis443
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发表时间：
2012-09-15
影响因子：
6.4
通讯作者：
Merkel, Tod J.
中科院分区：
文献类型：
--
作者：
Warfel, Jason M.;Beren, Joel;Merkel, Tod J.
百日咳是一种由细菌病原体百日咳博德特氏菌引起的传染性急性呼吸道疾病。尽管人们普遍认为百日咳博德特氏菌是通过雾化的呼吸道飞沫传播的，但没有对照研究记录过百日咳的空气传播。我们利用狒狒百日咳模型来确定受感染动物和幼稚动物之间是否发生空气传播。我们的结果表明，即使身体接触被阻止，接触过的幼稚动物 100% 也会被感染，这表明百日咳是通过雾化的呼吸道飞沫传播的。
Pertussis is a contagious, acute respiratory illness caused by the bacterial pathogen Bordetella pertussis. Although it is widely believed that transmission of B. pertussis occurs via aerosolized respiratory droplets, no controlled study has ever documented airborne transmission of pertussis. We set out to determine if airborne transmission occurs between infected and naive animals, utilizing the baboon model of pertussis. Our results showed that 100% of exposed naive animals became infected even when physical contact was prevented, demonstrating that pertussis transmission occurs via aerosolized respiratory droplets.