Diagnostic Prospectives with Tau Protein and Imaging Techniques to Detect Development of Chronic Traumatic Encephalopathy.
Diagnostic Prospectives with Tau Protein and Imaging Techniques to Detect Development of Chronic Traumatic Encephalopathy.
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DOI：
10.4236/jbbs.2023.134005
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发表时间：
2023-04
期刊：
影响因子：
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通讯作者：
Banerjee A
中科院分区：
文献类型：
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作者：
Naskar A;Jayanty D;Head K;Khanna GL;Vatsalya V;Banerjee A
在拳击、摔跤和其他格斗运动中，因反复击打而遭受的脑损伤会对身心健康造成严重后果。慢性创伤性脑病（CTE）这种退行性脑部疾病在临床上表现为记忆力减退、攻击性、理性思维困难以及其他认知问题。这种类似阿尔茨海默病的症状群，在许多职业运动员中是通过死后的脑活检来诊断的。然而，对于其发展过程以及如何识别可能患上CTE的易感个体，我们知之甚少。拳击是一项对运动员健康，尤其是大脑健康和功能造成严重损害的运动。这篇综述阐述了脑损伤相关的问题，描述了在多个层面（例如分子层面和认知层面）显现的病理情况，还提出了可能的诊断和预后标志物，以表征CTE的早期发病情况，同时旨在确定未来预防措施和干预的起点。
Brain damage sustained from repeated blows in boxing, wrestling, and other combat sports has serious physical and mental health consequences. The degenerative brain disease, chronic traumatic encephalopathy (CTE), presents clinically with memory loss, aggression, difficulty in rational thinking and other cognitive problems. This spectrum, which mimics Alzheimer’s disease, is diagnosed post-mortem through a brain biopsy in many professional athletes. However, little is known about the process of development and how to identify vulnerable individuals who may be on course for developing CTE. Boxing is a sport that has a severe toll on athletes’ health, primarily on their brain health and function. This review addresses the concerns of brain injury, describes the pathologies that manifest in multiple scales, e.g., molecular and cognitive, and also proposes possible diagnostic and prognostic markers to characterize the early onset of CTE along with the aim to identify a starting point for future precautions and interventions.