OXYGEN FREE-RADICAL INVOLVEMENT IN ISCHEMIA AND REPERFUSION INJURY TO BRAIN
OXYGEN FREE-RADICAL INVOLVEMENT IN ISCHEMIA AND REPERFUSION INJURY TO BRAIN
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DOI：
10.1016/0304-3940(88)90132-2
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发表时间：
1988-05-26
影响因子：
2.5
通讯作者：
CHEVION, M
中科院分区：
文献类型：
--
作者：
CAO, W;CARNEY, JM;CHEVION, M
本文提出了沙鼠脑缺血再灌注过程中氧自由基增加的证据。水杨酸盐与羟基自由基反应生成二羟基苯甲酸（DHBA），用作体内捕获剂。脑缺血至少5分钟，然后再灌注产生显着增加脑DHBA。无再灌注或仅缺血2min再灌注，DHBA的产生不增加。脑内DHBA水平的增加与沙土鼠缺血再灌注介导的行为改变相关，但水杨酸盐给药并不能保护沙土鼠的行为改变。
Evidence is presented which implicates increased oxygen free radicals during ishcemia-reperfusion of gerbil brain. Salicylate, which reacts with hydroxyl free radicals to yield dihydroxybenzoic acid (DHBA), was used as an in vivo trap. Brain ischemia for at least 5 min followed by reperfusion yielded significantly increased brain DHBA. Without reperfusion or with only 2 min of ischemia and then reperfusion, the production of DHBA was not increased. Increased levels of DHBA in brain correlated with ischemia reperfusion-mediated behavioral modification of gerbils, but salicylate administration did not protect against the behavior changes.