Dietary Weight Loss, Exercise, and Oxidative Stress in Postmenopausal Women: A Randomized Controlled Trial.
Dietary Weight Loss, Exercise, and Oxidative Stress in Postmenopausal Women: A Randomized Controlled Trial.
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DOI：
10.1158/1940-6207.capr-16-0163
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发表时间：
2016-11
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影响因子：
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通讯作者：
McTiernan A
中科院分区：
文献类型：
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作者：
Duggan C;Tapsoba JD;Wang CY;Campbell KL;Foster-Schubert K;Gross MD;McTiernan A
Oxidative stress, a potential mechanism linking obesity and cancer, results from an imbalance between activation/inactivation of reactive oxygen species, byproducts of cellular metabolism. In a randomized controlled trial we investigated effects of diet and/or exercise on biomarkers of oxidative stress. 439 overweight/obese (body mass index (BMI)>25 kg/m2) postmenopausal women, 50–75 years, were randomized to 12-months of (1) reduced-calorie weight loss diet (‘diet’; n=118), (2) moderate- to-vigorous intensity aerobic exercise (‘exercise’; n=117), (3) combined diet and exercise intervention (‘diet+exercise’; n=117), or (4) control (n=87). Outcomes were circulating markers of oxidative stress including Fluorescent Oxidation Products (FOP), F2-isoprostanes, and oxidized-LDL. On average participants were 57.9 years, with a BMI of 30.9 kg/m2. F2-Isprostanes were significantly reduced in the diet (−22.7%, P=0.0002), and diet+exercise (−23.5%, P<0.0001) arms vs. controls (−2.99%); and non-significantly reduced in the exercise arm (−14.5%, P=0.01). Participants randomized to the diet and diet+exercise arms had significant increases in levels of FOP (control −5.81%; diet +14.77% (P=0.0001); diet+exercise +17.45%, (P=0.0001)). In secondary analyses, increasing weight loss was statistically significantly associated with linear trends of greater reductions in oxidized-LDL and in F2-isoprostanes, and increases in FOP. Compared to controls, exercise participants whose maximal oxygen consumption increased had significant decreases in levels of F2-isoprostanes and in oxidized-LDL, and increases in FOP. Dietary weight loss, with or without exercise, significantly reduced some markers of oxidative stress in postmenopausal women.
