A DNA logic gate based on strand displacement reaction and rolling circle amplification, responding to multiple low-abundance DNA fragment input signals, and its application in detecting miRNAs
A DNA logic gate based on strand displacement reaction and rolling circle amplification, responding to multiple low-abundance DNA fragment input signals, and its application in detecting miRNAs
复制标题
基于链置换反应和滚环扩增的DNA逻辑门，响应多个低丰度DNA片段输入信号，及其在检测miRNA中的应用
DOI：
10.1039/c5cc01389e
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发表时间：
2015-01-01
影响因子：
4.9
通讯作者：
Zhou, Xiang
中科院分区：
文献类型：
--
作者：
Chen, Yuqi;Song, Yanyan;Zhou, Xiang
基于链置换反应和滚环扩增策略，设计了一种简便扩增的DNA与逻辑门平台，用于低丰度DNA片段输入的高灵敏检测。与其他检测系统相比，该系统可以检测生物样品中的miRNAs。这一策略的成功证明了DNA逻辑门在疾病诊断中的潜力。
A conveniently amplified DNA AND logic gate platform was designed for the highly sensitive detection of low-abundance DNA fragment inputs based on strand displacement reaction and rolling circle amplification strategy. Compared with others, this system can detect miRNAs in biological samples. The success of this strategy demonstrates the potential of DNA logic gates in disease diagnosis.