Human cytomegalovirus UL131A, UL130 and UL128 genes are highly conserved among field isolates
Human cytomegalovirus UL131A, UL130 and UL128 genes are highly conserved among field isolates
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DOI：
10.1007/s00705-005-0696-5
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发表时间：
2006-06-01
影响因子：
2.7
通讯作者：
Gerna, G.
中科院分区：
文献类型：
--
作者：
Baldanti, F.;Paolucci, S.;Gerna, G.
人巨细胞病毒(HCMV)UL131AUL130和UL128基因编码序列在34株人巨细胞病毒(HCMV)原发感染孕妇及其胎儿或新生儿、实体器官移植受者和艾滋病患者的野外分离株中高度保守。未观察到菌株聚集性。相反，对UL55(GB编码基因)进行测序，可以将34株分离物分为4个基因类型。UL131a-UL128位点的保守性与这三种编码蛋白都是人巨细胞病毒在内皮细胞中的生长和病毒向白细胞转移所必需的结论是一致的。
Coding sequences of the UL131A, UL130, and UL128 genes of human cytomegalovirus (HCMV) were found to be highly conserved among 34 field isolates from pregnant women with primary HCMV infection and their fetuses or newborns, as well as from solid organ transplant recipients and patients with AIDS. No strain clustering was observed. In contrast, sequencing of UL55 (gB coding gene) allowed the 34 isolates to be clustered into 4 genotypes. The conservation of the UL131A-UL128 locus is consistent with the conclusion that the three encoded proteins are all essential for growth of HCMV in endothelial cells and virus transfer to leukocytes.