Nicotine Delivery to the Aerosol of a Heat-Not-Burn Tobacco Product: Comparison With a Tobacco Cigarette and E-Cigarettes
Nicotine Delivery to the Aerosol of a Heat-Not-Burn Tobacco Product: Comparison With a Tobacco Cigarette and E-Cigarettes
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DOI：
10.1093/ntr/ntx138
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发表时间：
2018-08-01
影响因子：
4.7
通讯作者：
Poulas, Konstantinos
中科院分区：
文献类型：
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作者：
Farsalinos, Konstantinos E.;Yannovits, Nikoletta;Poulas, Konstantinos
简介：目的是测量烟草中的尼古丁水平以及与电子烟（EC）和烟草香烟相比，加热不燃烧产品（HnB，IQOS）的气雾剂中释放的尼古丁水平。方法：HnB设备以及普通和薄荷烟棒从意大利购买。还测试了三种类型的EC（雪茄样、eGo型和可变瓦数）和市售烟草香烟。使用含有2%尼古丁的定制液体与EC一起使用。使用加拿大卫生部的强烈抽吸方案对产品进行测试，同时使用4秒的抽吸持续时间方案对HnB和EC进行额外测试，同时保持相同的抽吸体积。常规和薄荷醇HnB产品的气雾剂尼古丁水平相似（分别为1.40 +/- 0.16和1.38 +/- 0.11 mg/12喷），并且随着喷烟持续时间的延长没有显著变化。（1.99 +/- 0.20 mg/支），其水平高于加拿大卫生部强化方案下的HnB和EC，但与延长抽吸持续时间方案下的eGo型和可变瓦数EC相似。当使用加拿大卫生部强烈抽吸方案进行测试时，HnB产品将尼古丁以高于EC但低于烟草卷烟的水平递送到气雾剂中。在相同的抽吸体积下，在延长的抽吸持续时间下没有观察到HnB尼古丁递送的变化，这与EC不同，EC在更长的抽吸持续时间下递送更多的尼古丁。
Introduction: The purpose was to measure nicotine levels to the tobacco and levels emitted to the aerosol of a heat-not-burn product (HnB, IQOS) compared to e-cigarettes (ECs) and a tobacco cigarette.Methods:The HnB device and regular and menthol sticks were purchased from Italy. Three types of ECs (ciga-like, eGo-style, and variable wattage) and a commercially-available tobacco cigarette were also tested. A custom-made liquid containing 2% nicotine was used with ECs. Products were tested using Health Canada Intense puffing regime while HnB and ECs were additionally tested using a 4-second puff duration regime while maintaining the same puff volume.Results: Nicotine content in HnB regular and menthol tobacco sticks was 15.2 +/- 1.1 mg/g and 15.6 +/- 1.7 mg/g tobacco respectively. The levels of nicotine to the aerosol were similar for regular and menthol HnB products (1.40 +/- 0.16 and 1.38 +/- 0.11 mg/12 puffs respectively) and did not change significantly with prolonged puff duration.The tobacco cigarette delivered the highest level of nicotine (1.99 +/- 0.20 mg/cigarette), with levels being higher than HnB and ECs under Health Canada Intense regime but similar to eGo-style and variable wattage ECs at prolonged puff duration regime.Conclusions:The HnB product delivers nicotine to the aerosol at levels higher than ECs but lower than a tobacco cigarette when tested using Health Canada Intense puffing regime. No change in HnB nicotine delivery was observed at prolonged puff duration with the same puff volume, unlike ECs which deliver more nicotine with longer puff duration.