Circulating microRNA-26a: Potential predictors and therapeutic targets for non-hypertensive intracerebral hemorrhage
Circulating microRNA-26a: Potential predictors and therapeutic targets for non-hypertensive intracerebral hemorrhage
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循环 microRNA-26a：非高血压性脑出血的潜在预测因素和治疗靶点
DOI：
10.1016/j.mehy.2011.06.017
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发表时间：
2011-10-01
影响因子：
4.7
通讯作者：
Hui, Rutai
中科院分区：
文献类型：
--
作者：
Bai, Yongyi;Wang, Liang;Hui, Rutai
非高血压性脑出血（ICH）的病理、发病机制和遗传背景可能与高血压性脑出血不同，其发病机制尚不清楚。microRNA是一类新的内源性小RNA，在转录后水平负调控基因表达。以往的研究表明，血管平滑肌细胞（VSMC）功能在非高血压性脑出血中起重要作用。miRNA-26 a是VSMC功能的关键调节因子，是可以在健康人体中检测到的无细胞miRNA之一。因此，我们推测循环中的miR-26 a可能是非高血压性脑出血的预测因子和治疗靶点。(C)2011年由Elsevier Ltd.出版
The mechanisms of non-hypertensive intracerebral hemorrhages (ICH), which may have different pathologies, mechanisms and genetic background from hypertensive ICH, are not clear. MicroRNAs are a new class of endogenous small RNAs that negatively regulate gene expression at the posttranscriptional level. Previous studies indicate that vascular smooth muscle cell (VSMC) function places important role in non-hypertensive ICH. MiRNA-26a, a pivotal regulator of VSMC function, is one of the cell-free miRNAs that could be detected in healthy humans. Therefore, we get the hypotheses that circulating miR-26a is a potential predictors and therapeutic targets for non-hypertensive ICH. (C) 2011 Published by Elsevier Ltd.