Assessing the Behavioral Consequences of Multiple Sclerosis: An Application of the Frontal Systems Behavior Scale (FrSBe)
Assessing the Behavioral Consequences of Multiple Sclerosis: An Application of the Frontal Systems Behavior Scale (FrSBe)
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DOI：
10.1097/00146965-200303000-00007
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发表时间：
2003-03-01
影响因子：
1.4
通讯作者：
DeLuca, John
中科院分区：
文献类型：
--
作者：
Chiaravalloti, Nancy D.;DeLuca, John
目的：本研究探讨额叶系统行为量表(FrSBe)在记录多发性硬化症(MS)患者行为改变中的作用。背景：多发性硬化症导致广泛的中枢神经系统损害，有影响额叶和顶叶脑区的倾向。方法：对26例MS患者和15例健康对照(HC)进行神经心理测试，并完成额叶系统行为量表(FrSBe)和情绪功能测量。结果：MS组发病前行为评分与HC组相当。然而，在患病后，三个FrSBe量表中的两个在临床和统计学上显著增加，这三个量表是冷漠量表和执行功能障碍量表。还注意到FrSBe家庭和患病后自我报告表以及神经心理表现的测量之间的关系，特别是信息处理、工作记忆和执行控制。相反，躯体疾病的进展与家庭的行为评分有关，而与自我评分无关。结论：家庭行为改变的自我评分和家庭对行为改变的评分与神经心理表现的测量有关。然而，多发性硬化症的身体症状只与家庭行为评级有关。
Objective:The current study examines the utility of the Frontal Systems Behavior Scale (FrSBe) to document behavioral changes in people with multiple sclerosis (MS).Background:MS results in widespread central nervous system lesions that have a propensity for affecting frontal and parietal brain regions. As a result, behavioral symptoms may present, including disorders of executive functioning, apathy, and disinhibition.Method:Twenty-six people with MS and 15 healthy controls (HC) underwent neuropsychological testing and completed the Frontal Systems Behavior Scale (FrSBe), and measures of emotional functioning.Results:Behavioral ratings for the MS group prior to illness were equivalent to those of the HC group. After illness however, a clinically and statistically significant increase was noted on two of three FrSBe scales, the apathy scale and the executive dysfunction scale. Relationships were also noted between the FrSBe family and self-report forms after illness and measures of neuropsychological performance, particularly information processing, working memory, and executive control. In contrast, physical disease progression was correlated with family ratings of behavior, but not self-ratings.Conclusions:The FrSBe appears to be a sensitive measure of behavioral change in people with MS. Self-ratings and family ratings of behavioral changes are related to measures of neuropsychological performance. However, physical symptoms of MS are related only to the family ratings of behavior.