Nickel-Catalyzed Decarbonylative Borylation and Silylation of Esters
Nickel-Catalyzed Decarbonylative Borylation and Silylation of Esters
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镍催化酯的脱羰硼化和硅烷化
DOI：
10.1021/acscatal.6b01956
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发表时间：
2016-10-01
期刊：
影响因子：
12.9
通讯作者：
Shi, Zhuangzhi
中科院分区：
文献类型：
--
作者：
Pu, Xinghui;Hu, Jiefeng;Shi, Zhuangzhi
镍催化的酚酯直接硼化和硅烷化反应已经建立。这种高效酰基C-O键硼基化和甲硅烷基化裂解的关键取决于在镍催化剂存在下适当选择不同的配体和添加剂。两种转化都表现出良好的官能团兼容性，可以作为复杂化合物后期功能化的强大合成工具。两种充分表征的有机镍（II）中间体证实了这种新开发的酯中酰基 C-O 键活化的关键机制特征。
The nickel-catalyzed direct borylation and silylation of phenolic esters has been established. The key to this highly efficient acyl C-O bond borylative and silylative cleavage depends on the appropriate choice of different ligands and additives in the presence of nickel catalyst. Both transformations exhibit good functional group compatibility and can serve as powerful synthetic tools for late-stage functionalization of complex compounds. The elucidation of key mechanistic features of this newly developed acyl C-O bond activation in esters was confirmed by two well-characterized organonickel(II) intermediates.