CARDIOMYOPATHY OF THE AGING HUMAN HEART - MYOCYTE LOSS AND REACTIVE CELLULAR HYPERTROPHY
CARDIOMYOPATHY OF THE AGING HUMAN HEART - MYOCYTE LOSS AND REACTIVE CELLULAR HYPERTROPHY
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DOI：
10.1161/01.res.68.6.1560
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发表时间：
1991-06-01
影响因子：
20.1
通讯作者：
ANVERSA, P
中科院分区：
文献类型：
--
作者：
OLIVETTI, G;MELISSARI, M;ANVERSA, P
为了确定衰老对人类心肌的影响，从死于心血管疾病以外的原因的个体中获得了67个心脏。 检查的年龄段为17-90岁。 回归分析表明，衰老过程的特点是在左心室和右心室心肌中分别损失3800万和1400万个肌细胞核/年。 这种肌肉质量的损失伴随着两个心室中每个核的肌细胞体积的进行性增加。 左心室肌细胞扩大110 mu-m3/yr，而右心室肌细胞增加118 mu-m3/yr，导致心室壁厚度的保存。 然而，细胞肥大反应不能维持正常的心脏质量。 左心室和右心室重量分别降低0.70和0.21 g/年。 总之，细胞的损失和剩余的心肌细胞的扩大可能代表老年心脏代偿能力降低的结构基础，并一起可能导致老年人心肌功能障碍和衰竭的发展。
To determine the effects of aging on the human myocardium, 67 hearts were obtained from individuals who died from causes other than cardiovascular disease. The age interval examined was 17-90 years. Regression analysis demonstrated that the aging process was characterized by a loss of 38 million and 14 million myocyte nuclei/yr in the left and right ventricular myocardium, respectively. This loss in muscle mass was accompanied by a progressive increase in myocyte cell volume per nucleus in both ventricles. Left ventricular myocytes enlarged by 110 mu-m3/yr, whereas right ventricular myocytes increased by 118 mu-m3/yr, resulting in a preservation of ventricular wall thickness. However, the cellular hypertrophic response was unable to maintain normal cardiac mass. Left and right ventricular weights decreased by 0.70 and 0.21 g/yr, respectively. In conclusion, loss of cells and enlargement of the remaining myocytes may represent the structural basis for the reduced compensatory capacity of the aged heart and together may contribute to the development of myocardial dysfunction and failure in the elderly.